Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

By S. Eden, R. Rohatgi, A. Podtelejnikov, Matthias Mann, Marc Kirschner. Nature, 2002

877 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/979391d523356bef2c39ed090b813694a1898151

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Citations in the corpus

• Rho GTPases: biochemistry and biology. (2005, background): “Progress in understanding this signal transduction pathway has also come from a biochemical approach, which has led to the isolation of a complex containing WAVE1, along with three other proteins, HSPC300, Nap125, and PIR121 (Eden et al. 2002).”
• The role of the Rho GTPases in neuronal development. (2005, background): “Since CYFIP is in a complex with both FMRP and WAVE1, it is likely to coordinate the regulation of actin cytoskeletal reorganization, as well as the control of local protein translation, processes that are key to neuronal morphogenesis and connectivity (Billuart and Chelly 2003; Schenck et al. 2003)”
• Regulation of actin assembly associated with protrusion and adhesion in cell migration. (2008, background): “WAVE1, -2, and -3 are part of a stable complex with four other proteins including Nap1 (Nck-associated protein), PIR121 (p53-inducible mRNA), HSPC300 (hematopoietic stem progenitor cell 300), and Abi1 (Abl-interactor 1) (55, 211).”
• Analysis of the myosinII-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation (2011, background): “55 ; only present in blebbistatin-treated focal adhesions) and N-WAS”
• Rac and Rho GTPases in cancer cell motility control (2010, background): “Seevaral Racrelated proteins, sharing more than 80% identity, they stimulate the formation of lamellipodia and membrane ruffles, presumably through interaction with the WAVE complex [14].”
• Cell migration: Rho GTPases lead the way. (2004, background): “Rac activates the Scar/WAVE family indirectly and this involves an Nck-adaptor complex (Eden et al., 2002; Rohatgi et al., 2001).”
• GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo (2007, background): “This is at least the case of Wasf/Wave/Scar proteins, which get released from an inhibitory complex formed with Nckap1–Nap125, Cyfip2–Pir121 and C3orf10–Hspc300 upon the binding of GTP-bound Rac1 to Nckap1 and Cyfip2.(49) It should be noted, however, that the binding of the activated GTPase results ”
• Rho-family GTPases: it's not only Rac and Rho (and I like it) (2004, background): “All the Rac-related proteins stimulate the formation of lamellipodia and membrane ruffles, presumably through interaction with the PIR121-Nap125-HSPC300-WAVE complex (Eden et al., 2002).”