Structure, regulation and function of PKB/AKT--a major therapeutic target.

By M. Hanada, Jianhua Feng, B. Hemmings. Biochimica et Biophysica Acta, 2004

779 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f1106359e61448e7f5456ba9da22ff23d2eef35f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. David M. Sabatini
2. E. White
3. C. Thoreen
4. D. Guertin
5. A. Newton
6. Tianyan Gao
7. Robin Mathew
8. Jason Moffat

Citations in the corpus

• Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. (2006, background): “Indeed, AKT synergizes with antiapoptotic BCL-xL to promote leukemogenesis (Karnauskas et al., 2003) and has prominent roles in regulating cell growth and metabolism that contribute to tumorigenesis (Hanada et al., 2004).”
• Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways (2005, background): “In a simplified scheme, it can be generalized that PI3K–Akt via mTOR plays a central role in growth control by controlling ribosomal biogenesis and activity of the translation machinery, whereas other downstream effectors play dominant roles in cell survival through phosphorylation of the cytoskelet”
• PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (2005, background): “Much progress has been made in the past decade in elucidating the mechanisms that lead to Akt phosphorylation and activation (Hanada et al., 2004).”
• Defining the role of mTOR in cancer. (2007, background): “In mammals, there are three AKT isoforms, each encoded by a unique gene (Hanada et al., 2004).”
• Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. (2006, background): “Thus, mTORC2-dependent phosphorylation of Akt/PKB at S473 is required for its in vitro activity. rictor and mLST8 Are Required to Maintain PKCa Phosphorylation and Expression, but Not Cytoskeletal Integrity Akt/PKB, S6K1, and SGK belong to the AGC family of kinases, which also includes RSK and PKCa ”