Energy balance and cancer: the role of insulin and insulin-like growth factor-I

By Rudolf Kaaks, A. Lukanova. Proceedings of the Nutrition Society, 2001

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Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. (2009, background): “In addition, compensatory hyperinsulinemia increases IGF bioavailability by decreasing IGF binding protein (IGFBP)-1 and IGFPB-2 (205).”
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms (2004, background): “Nutritional energy balance can have profound effects on the synthesis and biological activity of IGF1 (for reviews, see Ref”
Mechanisms linking physical activity with cancer (2008, neutral): “gov/cancertopics/types/pancreatic">pancreas and endometrial cancer”
Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, background): “In addition, insulin and IGF1 inhibit sex-hormone binding globulin (SHBG) synthesis, although both hormones stimulate ovarian synthesis of sex steroids that can promote cellular proliferation and inhibit apoptosis in breast epithelium and endometrium.(416,425) Furthermore, the increased risk of canc”
Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC). (2015, neutral): “Insulin acts as a growth factor increasing the bioactivity of the cancer-promoting insulin-like growth factor-1 (IGF-1) which has proliferatory, angiogenic, anti-apoptotic and estrogen-stimulating properties [94,95].”