Trends in insulin resistance: insights into mechanisms and therapeutic strategy
By Mengwei Li, Xiaowei Chi, Ying Wang, Sarra Setrerrahmane, Wenwei Xie, Hanmei Xu. Signal Transduction and Targeted Therapy, 2022
769 citations recorded by the source corpus.
The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key peptide hormone and mediates the systemic glucose metabolism in different tissues. Insulin resistance (IR) is a disordered biological response for insulin stimulation through the disruption of different molecular pathways in target tissues. Acquired conditions and genetic factors have been implicated in IR. Recent genetic and biochemical studies suggest that the dysregulated metabolic mediators released by adipose tissue including adipokines, cytokines, chemokines, excess lipids and toxic lipid metabolites promote IR in other tissues. IR is associated with several groups of abnormal syndromes that include obesity, diabetes, metabolic dysfunction-associated fatty liver disease (MAFLD), cardiovascular disease, polycystic ovary syndrome (PCOS), and other abnormalities. Although no medication is specifically approved to treat IR, we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin sensitivity. Ultimately, the systematic discussion of complex mechanism will help to identify potential new targets and treat the closely associated metabolic syndrome of IR.
Subfields: Biochemistry, Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/4f637aea591674734a6bf370f28c1f8ae9e05a38
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
Citations in the corpus
- Epidemiology of metabolic dysfunction-associated steatotic liver disease (2024, background): “[55,56] In a study from the United States, investigators determined that approximately 40% of young adults (18-44 years old) had IR and IR was more prevalent in those with a higher BMI, those with hypertension, and or hypercholesteremia and those of Mexican American ethnicity.”