Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

By E. Calle, Rudolf Kaaks. Nature Reviews. Cancer, 2004

3,625 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/4d5eaef243a471e0478d7dbf1b9b170caa3d2c5f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Guobin He
2. Herbert Tilg
3. A. Moschen
4. M. Karin
5. N. Perkins
6. S. Ghosh
7. M. Hayden
8. Bharat B. Aggarwal

In Molecular Biology

1. Guobin He
2. G. De Pergola
3. Funda Meric-Bernstam
4. M. Karin
5. Sushil Kumar Jain
6. D. Haller
7. B. Cravatt
8. G. A. Weiss

In Oncology

1. Guobin He
2. M. Karin
3. R. C. V. van Kruijsdijk
4. G. De Pergola
5. M. Hung
6. M. Thun
7. E. van der Wall
8. F. Visseren

Citations in the corpus

• Mechanisms and consequences of intestinal dysbiosis (2017, background): “Interestingly, an increased inflammatory state in obese individuals correlates with higher risk of colorectal cancer [221].”
• Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. (2011, background): “Obesity, wherein the normal balance of adipose tissue secretory proteins is disturbed, has been recently identified as a negative prognosis factor for breast cancer (9, 10).”
• American Cancer Society guidelines on nutrition and physical activity for cancer prevention (2002, background): “5 times the risk of developing the disease and, in the United States, approximately 60% of the disease being attributed to obesity.(246) In premenopausal women, insulin resistance, elevation in ovarian androgens, anovulation, and chronic progesterone deficiency associated with overweight may explain”
• Obesity and Cancer: The Role of Dysfunctional Adipose Tissue (2009, background): “Peripheral conversion of androgenic precursors to estradiol by aromatase in adipose tissue is increased in obesity, leading to increased serum levels of estradiol, which, in turn, are insufficiently counterbalanced by levels of progesterone (47, 132).”
• Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis (2010, background): “It has been postulated that excessive fat accumulation may exacerbate the development and progression of cancer (Calle and Kaaks, 2004; Calle et al., 2003), and, conversely, reductions in caloric intake have been shown to impede tumor growth (Kalaany and Sabatini, 2009).”
• Global Burden of Cancer (2006, background): “Obesity and excessive weight have been linked to many types of cancers, including those of the colon, breast, and prostate [17].”
• Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection (2010, background): “Hyperinsulinemia up-regulates the production of insulin-like growth factor-1 (IGF1), which is a peptide hormone that stimulates growth through cellular proliferation and inhibition of apoptosis within the liver.(93,111,112) Insulin also activates insulin receptor substrate-1 (IRS-1), which is involv”
• Obesity as a Major Risk Factor for Cancer (2013, background): “In endometrial cancer, heightened concentrations of plasma estradiol and estrone are correlated with increased cancer risk in postmenopausal obese women [66] and elevations of estradiol increase endometrial cell proliferation while inhibiting apoptosis and at the same time encouraging IGF-I synthesi”