Mechanisms linking physical activity with cancer

By A. McTiernan. Nature Reviews. Cancer, 2008

727 citations recorded by the source corpus.

Subfields: Oncology, Pediatrics, Perinatology and Child Health, Physiology

View Paper: https://www.semanticscholar.org/paper/33ead23ba8e8a9f4acd0cc2147e5f735c15fc3f2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. G. De Pergola
2. B. K. Pedersen
3. D. Shackelford
4. R. Shaw
5. F. Silvestris
6. Massimo F. Piepoli

In Pediatrics, Perinatology and Child Health

1. G. De Pergola
2. S. Devesa
3. B. K. Pedersen
4. D. Shackelford
5. R. Shephard
6. R. Shaw
7. F. Silvestris

In Physiology

1. G. De Pergola
2. B. K. Pedersen
3. D. Shackelford
4. R. Shephard
5. R. Shaw
6. F. Silvestris
7. Massimo F. Piepoli
8. M. C. Severinsen

Citations in the corpus

• Epidemiology and risk factors for kidney cancer (2010, background): “Physical activity Regular physical activity is associated with a reduced risk of several types of cancer, particularly colon and breast cancers”
• Obesity as a Major Risk Factor for Cancer (2013, background): “There have been several studies which show that physical exercise can lower breast cancer risk and that there are benefits both physical and mental for cancer patients [39].”
• The LKB1-AMPK pathway: metabolism and growth control in tumor suppression (2009, background): “Conversely, exercise and caloric restriction, each of which activates AMPK in some cell lineages, can lower overall cancer risk and improve cancer prognosi”
• Position statement. Part one: Immune function and exercise. (2011, background): “Nevertheless this hypothesis is based on limited evidence (168) and many studies have significant methodological limitations (283).”
• Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. (2016, positive): “Little is known about the mechanisms behind this protection, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immunecell function have been suggested as possible mediators (McTiernan, 2008).”
• LKB1 and AMPK control of mTOR signalling and growth (2009, background): “Conversely, exercise and caloric restriction, which both activate AMPK in some lineages, can lower overall cancer risk and improve cancer prognosis (McTiernan 2008).”