Non-canonical NF-κB signaling pathway

By Shao-Cong Sun. Cell Research, 2011

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The noncanonical NF‐κB pathway (2012, background): “Within the TRAF–cIAP E3 complex, TRAF2 serves as a linker to connect TRAF3 and cIAP1 ⁄2, as TRAF3 does not directly bind cIAP1 ⁄ 2 (5, 30, 33); this is why deficiency in either TRAF3 or TRAF2 leads to constitutive activation of the noncanonical NF-jB pathway (29, 54–57).”
Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches (2016, background): “The mammalian NF-κB family is composed of five members, including RelA (p65), RelB, c-Rel, NF-κB1 p50, and NF-κB2 p52, which form various dimeric complexes that transactivate numerous target genes via binding to the κB enhancer [2].”
30 years of NF-κB: a blossoming of relevance to human pathobiology (2017, neutral): “Lymphotoxin (LT) and LIGHT trigger the LTβ receptor (LTβR) to mediate development of peripheral lymph nodes and Peyer’s patches (Sun, 2011).”
The complexity of NF-κB signaling in inflammation and cancer (2013, background): “An alternative pathway of NF-κB activation, also designated as non-canonical pathway [34] (Figure 2B) originates from different classes of receptors including B-cell activation factor (BAFFR), lymphotoxin β-receptor (LTβR), CD40, receptor activator for nuclear factor kappa B (RANK), TNFR2 and Fn14 [”