Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines

By L. Luo, Takao K. Hensch, L. Ackerman, S. Barbel, L. Jan, Y. Jan. 1996

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. K. Vadodaria
2. Liqun Luo
3. E. Govek
4. S. Heasman
5. A. Hall
6. A. Schmidt
7. S. Newey
8. A. Ridley

Citations in the corpus

• Small GTPases Rac and Rho in the Maintenance of Dendritic Spines and Branches in Hippocampal Pyramidal Neurons (2000, methodology): “Previous transgenic expression of the activated allele Rac1V12 in Purkinje cells results in a slight simplification of dendritic complexity, a loss of normal dendritic spines, and the formation of supernumerary smaller protrusions that were only detectable with EM (Luo et al., 1996).”
• Filopodia: molecular architecture and cellular functions (2008, background): “This study provided the first evidence that the actin cytoskeleton is important for spine formatio”
• The role of the Rho GTPases in neuronal development. (2005, background): “…spines (Hinton et al. 1991; Irwin et al. 2001); in FMR1 knockout mice (Comery et al. 1997; Nimchinsky et al. 2001); and transgenic Rac1 mice (Luo et al. 1996a), supporting the idea that loss of FMRP may negatively affect Rac signaling, resulting in aberrant neuronal network formation and…”
• PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence (2014, unknown): “PAK inhibitors were tested to block spine deterioration due to prolonged overactivation of Rac1, which is elicited by DISC1 knockdown (10, 26, 27).”
• Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and Rho. (2000, unknown): “(Luo et al., 1996), we found that expression of a constitutively active form of Rac (Rac1V12) had a major effect on spine density and morphology (Figure 6).”
• Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1 (2010, background): “Long-term effects of DISC1 on dendritic spines Although activation of Rac1 initially leads to rapid spine growth, prolonged activation of Rac1 results in spine shrinkage in brain”
• Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases (2013, background): “…of the small GTPases during development, demonstrate diverse roles for Cdc42, Rac1 and RhoA in embryonic neurogenesis and neuronal maturation (Luo et al., 1996; Cappello et al., 2006, 2012; Chen et al., 2007; De Curtis, 2008; Fuchs et al., 2009; Haditsch et al., 2009; Leone et al., 2010;…”
• Mammalian Rho GTPases: new insights into their functions from in vivo studies (2008, background): “, and there were more but smaller dendritic spines in mice that express constitutively active RAC1 in Purkinje cell”
• β-catenin is critical for dendritic morphogenesis (2003, unknown): “During dendritic development, the regulation of actin dynamics by the small Rho GTPases is importan”
• Dentritic spines : structure, dynamics and regulation (2001, background): “Transgenic mice that expressed constitutively active Rac1 developed supernumerary dendritic spines of much smaller size than normal in cerebellar Purkinje cell”
• Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. (2002, background): “Kalirin is a Trio-like GEF that exists in various splice forms; one of these, Kalirin-7 (the rat homolog of human Duo), which contains only one DH domain specific for Rac, is enriched in the postsynaptic densities (PSD) specifically in dendritic spines.”
• RHO GTPASES in neuronal morphogenesis (2000, background): “Expression of constitutively active Rac had a similar selective effect on the growth of axons but not dendrites in cerebellar Purkinje cells in transgenic mic”
• Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. (2002, background): “For a number of years, Rac has been suggested to be a key regulator of dendritic spine morphogenesis (Luo et al. 1996a, Nakayama et al. 2000, Tashiro et al. 2000).”