RHO GTPASES in neuronal morphogenesis

By Liqun Luo. Nature Reviews Neuroscience, 2000

1,038 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/5a2111eb79cc76680019af70836745040a43ae7f

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Citations in the corpus

Adult hippocampal neurogenesis, Rho kinase inhibition and enhancement of neuronal survival. (2013, background): “Specifically for neurite outgrowth, Rac1 can induce neurite extension; while RhoA via its effector kinase Rho associated kinase (ROCK) leads to retraction and growth cone collapse (Kozma et al., 1997, Leeuwen et al., 1997, Luo, 2000).”
Structural plasticity and memory (2004, background): “Rho GTPases are intracellular signalling molecules that serve as a signalling switch and that can be an activated molecule bound to GTP or an inactive molecule bound to GD”
The Biology of Forgetting – A Perspective (2017, background): “Rac1-Dependent Forgetting Rac is a member of the Rho GTPase family of small G proteins (Etienne-Manneville and Hall, 2002; Luo, 2000).”
Axon pruning: an essential step underlying the developmental plasticity of neuronal connections (2006, background): “However, since the numbers of known Rho GTPases are fewer than the molecules that regulate their activity, recent findings have suggested that the regulatory molecules might play a more significant role in determining changes at the cytoskeleton, which ultimately can influence the morphology of deve”
Rho GTPases in cell biology (2002, background): “Cdc42 and Rac are positive regulators of neurite outgrowth, whereas Rho inhibits neurite extensio”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, neutral): “RhoA is a regulator of actin polymerization (Luo, 2000), but it is not known whether the BDNF-”
Forgetting is regulated through Rac activity in Drosophila. (2010, neutral): “development and activity-dependent structural plasticity where cytoskeleton remodeling is acutely required (Luo, 2000; Van Aelst and Cline, 2004).”
A decade of CDK5 (2001, background): “The Rho family of small GTPases is important in regulating actin dynamics, and members of this family are directly implicated in axon guidance, neurite outgrowth and cell motilit”
Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. (2002, background): “Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signaling to actin cytoskeletal dynamics.”
Cytoskeletal dynamics and transport in growth cone motility and axon guidance. (2003, neutral): “An important goal for the fu- be discussed here (Dickson, 2002; Huber et al., 2003; Lee and Van Vactor, 2003; Luo, 2000, 2002; Meyer andture will be to understand the coordinated response of the cytoskeleton to signaling cascades induced by Feldman, 2002; Mueller, 1999; Song and Poo, 2001).”
Scatter-factor and semaphorin receptors: cell signalling for invasive growth (2002, background): “In fibroblasts and neuronal cell lines, activation of RAC and CDC42 results in the formation of LAMELLIPODIA and FILOPODIA , respectively, whereas activation of RHO induces process retractio”
Trekking across the brain: the journey of neuronal migration. (2007, neutral): “Filamin 1 is able to interact with a diverse group of transmembrane proteins and serves as a scaffold for signaling proteins of the Rho family of GTPases, which are also implicated in neurite extension and neuronal migration (Dhavan and Tsai, 2001; Luo, 2000; Stossel et al., 2001).”
Central mechanisms of pathological pain (2010, background): “For example, the Rho/Rac families of GTPases transduce signals coming from extracellular stimuli (such as ephrins or glutamate) to the actin cytoskeleton and contribute to plasticity in dendritic spine”
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. (2002, background): “Over the intervening years, evidence has accumulated to show that in all eukaryotic cells, Rho GTPases are involved in most, if not all, actin-dependent processes such as those involved in migration, adhesion, morphogenesis, axon guidance, and phagocytosis (Kaibuchi et al. 1999; Chimini and Chavrier”