Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and Rho.

By A. Tashiro, A. Minden, Rafael Yuste. 2000

321 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

Citations in the corpus

• The role of the Rho GTPases in neuronal development. (2005, unknown): “CA Cdc42 also occasionally causes short dendrites in mouse hippocampal pyramidal neurons (Tashiro et al. 2000), and both CA and wild-type Cdc42 decrease dendrite number and length in Xenopus RGCs (Ruchhoeft et al. 1999).”
• Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1 (2010, unknown): “Long-term effects of DISC1 on dendritic spines Although activation of Rac1 initially leads to rapid spine growth, prolonged activation of Rac1 results in spine shrinkage in brain”
• Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS (2003, unknown): “N19RhoA is mostly insoluble when purified from bacteria (Self and Hall, 1995) and is a relatively weak inhibitor of Rho action (Tashiro et al., 2000).”
• Dentritic spines : structure, dynamics and regulation (2001, unknown): “cgi?l=5879">Rac1 disrupted the normal spine morphology of pyramidal neurons in slice culture, causing a net increase in dendritic protrusions (filopodia-like processes and LAMELLIPODIA -like ruffles”
• Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. (2003, unknown): “Since pharmacological and genetic perturbation of actin Potential Mechanisms by which Reorganized Spine Actin Cytoskeleton Promotes the Late dynamics affects spine structures (Meng et al., 2002; Nakayama et al., 2000; Pak et al., 2001; Penzes et al., Phase of LTP How can the reorganized spine actin ”