Mammalian MAP kinase signalling cascades

By Lufen Chang, M. Karin. Nature, 2001

5,303 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/efc382b175d9e0a5918c45b20716ff3dc6f25e71

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Citations in the corpus

Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution (2024, background): “For example activation of p38 and ERK MAPKs can induce the expression of ROS-producing a positive feedback loop [82,83].”
Role of oxidative modifications in atherosclerosis. (2004, background): “With respect to redox regulation of AP-1 activity, the first and third of these mechanisms appear most relevant and involve activation of the MAPK cascade (144).”
AP-1 as a regulator of cell life and death (2002, background): “These stimuli activate mitogen activated protein kinase (MAPK) cascade”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “The induction of AP-1 by H2O2, cytokines, and other stressors, for example, is mediated mainly by JNK and p38 MAPK cascades [173].”
The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. (2008, background): “JNK activation also plays an important role in regulating apoptosis (Chang and Karin, 2001; Davis, 2000; Yu et al., 2004).”
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. (2001, neutral): “As previously shown, PGC-1 coactivates the transcriptional function of the endogenous mitochondrial regulaet al., 1995, 1996; Chang and Karin, 2001).”
Fundamental Limits to Cellular Sensing (2015, background): “And many cellular signaling pathways, including two-component systems in bacteria [74], GTP-ase cycles as in the Ras system [63], phosphorylation cycles as in MAPK cascades [19], are driven out of thermal equilibrium via the turnover of fuel.”
Pathophysiology of Cisplatin-Induced Acute Kidney Injury (2014, background): “Cell cycle inhibitors and the cyclin-dependent kinase inhibitors p21 and p27 protect against cisplatin-induced tubular injury.”
NFAT proteins: key regulators of T-cell development and function (2005, background): “Cooperation between NFAT proteins and AP1 integrates two of the main signalling pathways that are induced in response to T-cell stimulation: calcium signalling, which is responsible for the activation of NFAT proteins; and the RAS–MAPK pathway, which induces the expression and activation of FOS and ”