Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

By P. Puigserver, James Rhee, Jiandie D. Lin, Zhidan Wu, J.Cliff Yoon, Chen-Yu Zhang, S. Krauss, Vamsi K. Mootha, Bradford B. Lowell, B. Spiegelman. Molecules and Cells, 2001

785 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/6723fd53f8b934c61162376c12cb67dac7e622ec

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. Chawla
2. J. Odegaard
3. Jianping Ye
4. P. Murray
5. B. Spiegelman
6. Lata Mukundan
7. Christoph Handschin
8. Jiandie D. Lin

In Molecular Biology

1. R. Scarpulla
2. B. Spiegelman
3. Christoph Handschin
4. J. Zierath
5. Jiandie D. Lin
6. D. Kelly
7. M. Hock
8. A. Kralli

In Physiology

1. R. Scarpulla
2. B. Spiegelman
3. J. Zierath
4. Christoph Handschin
5. Jiandie D. Lin
6. D. Kelly
7. M. Hock
8. A. Kralli

Citations in the corpus

• Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice (2009, background): “Their activities may contribute to elevation of the PGC-1α protein through enhancing protein stability (26-28).”
• Exercise metabolism and the molecular regulation of skeletal muscle adaptation. (2013, background): “PGC-1a activity is highly regulated by numerous posttranslational modifications including phosphorylation and deacetylation (Puigserver et al., 2001; Jäger et al., 2007; Cantó et al., 2009).”
• Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. (2006, background): “By interacting with tissue-specific transcription factors, the PGC-1 proteins regulate various cellular processes, including thermogenesis, muscle fiber type specification, gluconeogenesis, lipogenesis, and cytokine signaling (Lin et al., 2002,2005b;Puigserver et al., 1998,2001;Yoon et al., 2001).”
• Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “PGC-1a phosphorylation by p38MAPK, for example, is most likely involved in mediating the effects of cytokines.(65,66) An interesting observation made recently is that, in addition to increasing PGC-1a expression, AMPK can directly phosphorylate PGC-1a, this phosphorylation being required for the PGC”
• Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. (2005, background): “It was reported that P can be activated by a p38 MAPK-sensitive pathw nd that PPAR gene expression is dependent on APK activation (Puigserver et al., 2001).”