AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.

By Ching‐Yi Chen, R. Gherzi, Shao-En Ong, E. K. Chan, Reinout Raijmakers, G. Pruijn, G. Stoecklin, C. Moroni, Matthias Mann, M. Karin. Cell, 2001

932 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ef4cabff3518201c4948aa27481dfa9680745535

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Paul Anderson
2. N. Kedersha
3. R. Parker
4. R. Kaufman
5. O. Isken
6. L. Maquat
7. D. Scheuner
8. M. Kedde

Citations in the corpus

• MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “HuR-bound mRNAs are localized to polysomes for protein synthesis, whereas mRNAs bound by AUF1 are destined for degradatio”
• ZBP2 Facilitates Binding of ZBP1 to β-Actin mRNA during Transcription (2007, background): “KSRP is also known as fuse binding protein 2 (FBP), one of three vertebrate FBP family members (13, 41) found to participate in many steps of RNA metabolism, including transcription (14), pre-mRNA splicing (1, 25, 36, 41), mRNA editing (38), and exosome-mediated mRNA degradation (6, 20).”
• Cytoplasmic foci are sites of mRNA decay in human cells (2004, background): “Although several pathways for mRNA degradation have been observed and described in human cells (Couttet et al., 1997; Chen et al., 2001), the factors involved in these processes and their regulation have remained poorly characterized until recently.”
• Involvement of microRNA in AU-rich element-mediated mRNA instability. (2005, background): “TTP has been shown to bind to extended ARE equences by virtue of its zinc finger (Michel et al., 003) and associates with components of exosomes Chen et al., 2001); we have shown here that TTP is also ssociated with eiF2C/Ago family members.”
• A physical and functional map of the human TNF-α/NF-κB signal transduction pathway (2004, methodology): “The TAP procedure is a sensitive and selective method to purify, under close-to-physiological conditions, multiprotein complexes formed in vivo”
• RBPDB: a database of RNA-binding specificities (2010, background): “The RBPs TTP and members of the ELAV family have been implicated in the ARE-regulated degradation of c-fos RNA (37).”
• Stress granules and processing bodies are dynamically linked sites of mRNP remodeling (2005, background): “JCB • VOLUME 169 • NUMBER 6 • 2005872 this 3 –5 exosome-dependent pathway (Jacobs et al., 1998; Chen et al., 2001; Mukherjee et al., 2002).”
• Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “2003) as once thought (Brouwer et al. 2001; Chen et al. 2001).”
• The highways and byways of mRNA decay (2007, background): “The 37-kDa isoform of AUF1 interacts with the exosom”