Trained immunity: a memory for innate host defense.

By M. Netea, J. Quintin, J. van der Meer. Cell Host and Microbe, 2011

1,494 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ef2ce1a1e727516f9fd443402b96cca90085837c

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Citations in the corpus

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity (2016, background): “The biological relevance of innate immune memory is demonstrated by its broad presence in nature, with studies in organisms as diverse as plants, insects, cephalopods, and mammals reporting its impact for resistance to infections (Fu and Dong, 2013; Kurtz, 2005; Netea et al., 2011).”
How do plants achieve immunity? Defence without specialized immune cells (2012, background): “Similarly to investigations of SAR in plants, studies of immunity in invertebrate animals (which also do not have a typical adaptive immune response) show that primary pathogen exposure can induce life-long protection against secondary infectio”
Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes (2012, background): “We proposed the term “trained immunity” for the enhanced state of the innate immune responses following exposure to certain infectious agents, which may result in an increased resistance to reinfection (Netea et al., 2011).”
Microglial M1/M2 polarization and metabolic states (2016, background): “Modifications of the innate immune response The innate immune system is shaped and conditioned to subsequent responses for days or months following activation or immunological signals (Netea et al., 2011; Kleinnijenhuis et al., 2012).”
Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes (2014, background): “mechanism has been termed trained immunity.(11,12) In humans,”
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “Recently, this phenomenon has been re-named trained innate immunity (219).”
Immune Dysfunction as a Cause and Consequence of Malnutrition (2016, background): “These changes in innate cell function, also seen in response to BCG vaccination [74,76], are related to epigenetic reprogramming of monocytes and changes in their PRR repertoire [75].”
Metabolic Induction of Trained Immunity through the Mevalonate Pathway. (2018, unknown): “The induction of a non-specific memory resulting in an enhanced function of the innate immune system was termed ‘‘trained (innate) immunity’’ (Netea et al., 2011, 2016).”
Trained immunity: a program of innate immune memory in health and disease (2016, background): “Finally, the concept of innate immune memory has considerable potential in helping the design of novel therapeutic approaches, with at least three potential lines of investigation: (1) the design of new generation vaccines that combine adaptive and innate immune memory, as recently proposed with a n”