Phosphoinositides in cell regulation and membrane dynamics

By G. Paolo, P. Camilli. Nature, 2006

2,540 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eed141fe1b92ecb8dfbe31dd5be407b1254fd039

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Molecular Biology

Citations in the corpus

Autophagy pathway: Cellular and molecular mechanisms (2018, background): “kinases and phosphatases, which add or remove phosphate groups at various positions of the inositol ring, generate the unique PI signature of distinct membrane compartments.(65) So far, PtdIns3P, PtdIns4P and PtdIns(3,5)P2 have been shown to participate in autophagosome-lysosome fusion.”
Lipid signalling in disease (2008, background): “Phosphoinositides have, therefore, gained importance as localization tags that are involved in the organization of membrane-bound signalling complexe”
The emerging mechanisms of isoform-specific PI3K signalling (2010, background): “These include the lipid kinase FYVE finger-containing phosphoinositide kinase ( PIKfyve ; also known as FAB1), which converts PtdIns3P to PtdIns(3,5)P 2 , protein kinases (such as SGK3), GAPs (such as RGS domain- and PHOX domain-containing protein ( RGS-PX1 ; also known as SNX13)), the p40 and p47 s”
Lysosomal Physiology (2015, background): “Phosphoinositides are important regulators of membrane trafficking (89).”
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. (2007, background): “More generally, phosphoinositides have emerged as general determinants of membrane identity ( Di Paolo and De Camilli, 2006 ).”
Lipidomics: coming to grips with lipid diversity (2010, background): “The organization of the biosynthetic and endocytic compartments are aided by the specific distribution of phosphoinositide”
PIP2 is a necessary cofactor for ion channel function: how and why? (2008, background): “This localization is essential for their cell biological function (13).”
Role of Rab GTPases in Membrane Traffic and Cell Physiology (2011, background): “Both EEA1 and rabenosyn-5 also possess a FYVE domain that binds to the phosphoinositide PI(3)P, which is normally found on early endosomal membranes (103, 233, 296).”
Subcellular targeting strategies for drug design and delivery (2010, background): “Compartmentalization of RNA and lipids In addition to proteins, lipids and RNA molecules have been shown to be localized to distinct subcellular location”