PIP2 is a necessary cofactor for ion channel function: how and why?

By B. Suh, Bertil Hille. Annual Review of Biophysics, 2008

648 citations recorded by the source corpus.

How researchers see this paper

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Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “There is ample literature on the regulation of ion channels and transporters by phosphoinositides (488, 617, 932, 1138, 1285, 1487).”
SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function (2010, positive): “A discussion of lipid modulation of channel function would not be complete without mention of the best known lipid modulator, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) (Suh & Hille, 2008).”
PI(3,5)P2 Controls Membrane Traffic by Direct Activation of Mucolipin Ca2+ Release Channels in the Endolysosome (2010, methodology): “One method of 'chelating' PIPs is adding polycations such as polylysine to the cytoplasmic side of the membrane, where they bind the negatively charged phosphate head groups of PIPs in an electrostatic manne”
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. (2014, background): “Indeed, many ion channels and transporters require PI(4,5)P2 for proper functioning (Suh and Hille, 2008).”
The functional network of ion channels in T lymphocytes (2009, background): “A similar PIP2-channel interaction requirement is found in several other channel types (138).”