Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.

By R. Siegel, J. Frederiksen, D. Zacharias, F. Chan, Michele M. Johnson, D. Lynch, Roger Tsien, M. Lenardo. Science, 2000

712 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/ee82f9510ea032e91b87d2704d0ef353ec7bec6f

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Citations in the corpus

Life and death by death receptors (2009, background): “Ligand-independent receptor complex formation has also been suggested for TRAIL and Fas receptors (12, 13).”
The many roles of FAS receptor signaling in the immune system (2009, neutral): “This is consistent with the notion that extensive aggregation of multiple preassembled FAS trimers and not only FASL trimerFAS trimer interaction is required for apoptosis induction (Siegel et al., 2000).”
Studying protein dynamics in living cells (2001, background): “However, FRET studies using fusion proteins between Fas and CFP or YFP now show that Fas exists as a preassembled trimer on the cell surfac”
The CD95(APO-1/Fas) DISC and beyond (2003, methodology): “These interactions were found to be mediated by a domain in the Nterminus, within the first of the cysteine-rich domains.(3,4) This association was described by binding of in vitro generated proteins to cells transfected with CD95, and by the use of”
Viruses and apoptosis (2001, background): “It has until recently been assumed that trimerization of the CD95 receptor following binding of CD95L was essential for the formation of DISC, but recent reports suggest that receptor oligomers form in the absence of ligand-binding (Siegel et al. 2000).”
CD95's deadly mission in the immune system (2000, background): “To prevent the premature signalling of preassociated receptors, which is a dangerous situation, intracellular receptor-associated apoptosis blockers were postulate”
Proteases for Cell Suicide: Functions and Regulation of Caspases (2000, background): “Fas molecules preassemble into homotrimers via the preligand-binding assembly domain in the extracellular regions (19, 186).”
Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans (2005, background): “, or the idea that mutant and wild-type TACI might be preassociated in a ligand-independent manner, as has been suggested for Fa”