The CD95(APO-1/Fas) DISC and beyond

By Marcus E. Peter, P. Krammer. Cell Death and Differentiation, 2003

1,176 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dbabf0f52bfe556d38fa6443ed5202283197863b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Zhaoyu Jin
2. D. Lawrence
3. Jennie Lill
4. Yun Li
5. Victoria C. Pham
6. R. Pitti
7. M. Lamkanfi
8. T. Vanden Berghe

In Molecular Biology

1. Peter Vandenabeele
2. Zhaoyu Jin
3. D. Lawrence
4. Jennie Lill
5. Yun Li
6. Victoria C. Pham
7. R. Pitti
8. T. Vanden Berghe

Citations in the corpus

• MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “In the extrinsic apoptosis pathway, surface receptors of the death receptor family that include TNFRI, CD95 (Fas/APO-1) and the TNF-related apoptosis inducing ligand (TRAIL) receptors DR4 and DR5 (Schulze-Osthoff et al., 1998), once triggered by their cognate ligands, recruit adaptor proteins (FADD ”
• Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. (2009, positive): “In ‘‘type II’’ cells, further signal amplification is required; this occurs by caspase-8-mediated processing of the Bcl-2 homology domain 3 protein Bid, which engages the mitochondria to promote further caspase activation (Peter and Krammer, 2003).”
• Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. (2009, background): “…of various death-inducing cytokines including TNF-a, TRAIL, and CD95 ligand to their respective receptors leading to the activation of caspase-8 (Peter and Krammer, 2003); The intrinsic pathway is activated after mitochondrial intermembrane space proteins such as cytochrome c and Smac/Diablo…”
• Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. (2006, background): “When they bind their extracellular ligands they aggregate and initiate a signalling pathway that results either in cell survival or in death [27].”
• Caspases in cell survival, proliferation and differentiation (2007, background): “In contrast, caspase-8 processing and strong activation is seen during FasL-induced apoptosis (Figure 1a).(4) An important player in the regulation of caspase-8 activation at the level of the DISC is c-FLIPL, a caspase-8-like molecule that lacks caspase activity.”