CD95's deadly mission in the immune system

By P. Krammer. Nature, 2000

1,839 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d9a5d70bc8156b4d70fe584bce9fd2a2937d5b54

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Junying Yuan
2. D. Ofengeim
3. Guido Kroemer
4. L. Galluzzi
5. J. Tschopp
6. O. Micheau
7. K. Debatin
8. S. Nagata

In Immunology

1. Junying Yuan
2. D. Ofengeim
3. Guido Kroemer
4. S. Nagata
5. P. Jost
6. L. Galluzzi
7. Simone Fulda
8. K. Debatin

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Junying Yuan
4. Simone Fulda
5. D. Ofengeim
6. K. Debatin
7. J. Ameisen
8. C. Brenner

Citations in the corpus

• A guide to cell death pathways (2023, positive): “…activation of cytoplasmic membrane-localized death receptors that are characterized by the presence of an intracellular protein–protein interaction domain known as the Death domain (DD), such as Fas (also known as CD95), TNFR1, TRAIL (DR4) and TRAIL-R2 (DR5), by their cognate ligands 25,26 (Figs.”
• Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract (2004, background): “Some of the possibilities include decreased local proliferation, increased cell death in the effector compartment due to apoptosis or activation-induced cell death (36), reduced homing of cells to the effector site from the periphery after antigen recognition due to either direct cytopathic effects ”
• Viruses and apoptosis (2001, background): “Death receptors are a family of type I transmembrane proteins which belong to the tumour necrosis factor (TNF) receptor gene superfamily (Ashkenazi & Dixit 1998; Krammer 2000).”
• Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. (2001, background): “L’un des exemples les plus connu est la liaison CD95 (Apo-1/Fas)/CD95L qui induit l’agrégation en cascade de molécules « d’adaptation » (FADD pour Fas-associated death domain protein) puis de multiples molécules de procaspases-8 (protéases inactives ; caspase pour Cysteine ASPartate proteASE) qui, e”
• Serpins Promote Cancer Cell Survival and Vascular Cooption in Brain Metastasis (2014, neutral): “Although FasL plays important roles in immune homeostasis (Krammer, 2000) and is present in tumors (Baldini et al., 2009), its expression is particularly acute in reactive astrocytes (Beer et al., 2000).”