Caught up in a Wnt storm: Wnt signaling in cancer.

By R. Giles, J. van Es, Hans Clevers. Biochimica et Biophysica Acta, 2003

1,599 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ee1e31eaa717ea37a11f422cf034157aa5a239e9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

WNT and β-catenin signalling: diseases and therapies (2004, background): “Supporting this idea, any mutations that strongly and constitutively activate the β-catenin pathway are probably involved in the initiation and progression of cance”
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor (2004, background): “Aberrant activation of Wnt signaling has been implicated in cancer formation in numerous basic and clinical studie”
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. (2011, background): “Mutations in β-catenin have also been found in sporadic colon cancers [44].”
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. (2008, background): “Furthermore, h-catenin mutations have been identified in a majority of hepatoblastoma, the pediatric tumor believed to originate from hepatoblasts ( 43 ).”
Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19 (2018, background): “Abnormal activation of Wnt/β-catenin signaling is the initiating and driving event underlying the vast majority of CRC tumorigenesis [80, 81].”
Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. (2004, background): “Somatic mutations in b-catenin and molecules of the degradation complex have been found in cancer tissues, including skin, gastrointestinal, ovarian, and hepatocellular tumors (Huelsken and Birchmeier 2001; Giles et al. 2003; Lustig and Behrens 2003).”