Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites.

By J. Downs, S. Allard, Olivier Jobin-Robitaille, A. Javaheri, Andréanne Auger, N. Bouchard, S. Kron, Stephen P. Jackson, J. Côté. Molecules and Cells, 2004

629 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ed1ca6c930fd78d2c0ca4d565f23c7e8c2a40817

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Citations in the corpus

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. (2011, background): “gH2AX spreading was also described in yeast (Downs et al. 2004; Shroff et al. 2004), although over shorter distances: up to 100 kb as opposed to several megabases in mammals (Rogakou et al.”
Histone acetyltransferase complexes: one size doesn't fit all (2007, background): “One involves the recruitment of NuA4 following DNA-damage-mediated phosphorylation of histone H2A, and a second involves the phosphorylation of Ser1 of histone H4 (Ref”
γ-H2AX Dephosphorylation by Protein Phosphatase 2A Facilitates DNA Double-Strand Break Repair (2005, background): “However, recent studies have implicated two SNF2-family ATPase complexes in removing g-yH2A and g-H2AX by histone exchange: Ino80 in S. cerevisiae ( Downs et al., 2004; Morrison et al., 2004; van Attikum et al., 2004) and dTip60 in Drosophila (Kusch et al., 2004), respectively.”
Surviving the breakup: the DNA damage checkpoint. (2006, background): “A major role for γ-H2AX is the recruitment of chromatin remodelers, including the Ino80, Rvb1, NuA4, and Swr1 complexes to the DSB (12, 17, 35, 97, 110, 147).”
The biology of chromatin remodeling complexes. (2009, background): “A role for ARPs in histone interaction also has support, as certain ARPs are reported to have histone-binding activity in vitro (151).”
The γ‐H2A.X: Is it just a surrogate marker of double‐strand breaks or much more? (2008, background): “X [Downs et al., 2004; Kusch et al., 2004; Morrison et al., 2004; van Attikum et al., 2004; Stucki et al., 2005]. c-H2A.”
Chromatin challenges during DNA replication and repair. (2007, positive): “Although the exact purpose of this DSB-induced H2A-variant exchange is not known, it is likely important for DNA damage survival because loss of H2AZ and SWR1 function causes sensitivity to genotoxic agents (Downs et al., 2004).”