Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

By T. Oberlander, J. Weinberg, M. Papsdorf, Ruth E. Grunau, S. Misri, A. Devlin. Epigenetics, 2008

1,433 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/ec7f4fffee56f7acb1607720d117b531525b0713

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. Orna Zagoory-Sharon
2. Ilanit Gordon
3. Ruth Feldman
4. Inna Schneiderman
5. D. Wood
6. Marian F. Earls
7. Omri Weisman
8. B. Siegel

In Molecular Biology

1. Ruth Feldman
2. B. Blumberg
3. Frederica Perera
4. Julie Herbstman
5. J. Shonkoff

In Public Health, Environmental and Occupational Health

1. Ruth Feldman
2. M. Weinstock

Citations in the corpus

• The Lifelong Effects of Early Childhood Adversity and Toxic Stress (2012, background): “The precise biological mechanisms that explain these findings remain to be elucidated, but epigenetic modifications of DNA appear likely to play a role.(31,33,34) Early postnatal experiences with adversity are also thought to affect future reactivity to stress, perhaps by altering the developing neu”
• Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review (2014, neutral): “In studies of gestational stress, it is important to note that 4 studies collected tissue samples at birth (20, 28, 45, 47), and it is therefore unclear whether the observed changes would persist into adulthood.”
• Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent-infant contact. (2010, background): “, 2008) and benefit less from environmental enrichment (Parent and Meaney, 2008), and similar findings are observed for children of postnatally depressed mothers (Oberlander et al., 2008; Feldman et al., 2009; Murray et al., 2009).”
• Effects of Late Gestational High Fat Diet on Body Weight, Metabolic Regulation and Adipokine Expression in Offspring (2013, positive): “These assumptions have been corroborated significantly by studies involving prenatal stress (2-4) and induced maternal malnutrition (5).”
• Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy. (2017, background): “between maternal depression and anxiety during pregnancy and epigenetic changes in the methylation of NR3C1 in cord blood and infant salivary samples (Braithwaite et al., 2015; Hompes et al., 2013; Nemoda et al., 2015; Oberlander et al., 2008; Palma-Gudiel et al., 2015b).”
• Prenatal environmental exposures, epigenetics, and disease (2011, positive): “In a related study, newborns of mothers who had symptoms of depression during pregnancy had increased methylation of the glucocorticoid receptor gene in umbilical cord blood cells and the infants had elevated salivary cortisol concentrations at three month of age [41].”
• Endocrine Disrupting Chemicals and Disease Susceptibility (2011, background): “Many other chemicals have also been implicated in promoting toxicity for multiple generations, including BPA [66, 67], polycyclic hydrocarbons [68, 69], cocaine [69], pesticides [70], and phytoestrogens [71-73].”