The E2F1–3 transcription factors are essential for cellular proliferation
By Lizhao Wu, C. Timmers, B. Maiti, H. Saavedra, L. Sang, Gabriel T. Chong, Faison J. Nuckolls, P. Giangrande, F. Wright, S. Field and 5 more. Nature, 2001
673 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology, Ophthalmology
View Paper: https://www.semanticscholar.org/paper/4ae94f14d03c068610ce55411b7bb90c906c7c24
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In Molecular Biology
- Antonio Giordano
- C. Giacinti
- K. Helin
- P. Murphy
- Leigh-Ann MacFarlane
- D. Cobrinik
- E. L. Denchi
- J. Simon
In Oncology
In Ophthalmology
Citations in the corpus
- The E2F transcriptional network: old acquaintances with new faces (2005, methodology): “In agreement with this model, E2F4 and E2F5, which repress expression of S-phase genes, appear to be required for cell cycle exit and differentiation, and cells lacking repressor E2Fs fail to respond to certain cell cycle arrest signals (Mann and Jones, 1996; Gaubatz et al., 2000; Wu et al., 2001).”
- MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “E2Fs are critical regulatory components for apoptosis and cell proliferation [304-312].”
- Emerging roles of E2Fs in cancer: an exit from cell cycle control (2009, neutral): “Although the loss of E2f1–E2f3 leads to the complete arrest of mouse embryonic fibroblasts (MEFs) in cell culture and therefore supports this ide”
- RB and cell cycle progression (2006, background): “…by the loss of pRb but also by the loss of E2F1–3 proteins, so it is clear that E2F1–3 proteins act in this case as repressors instead of activators (Wu et al., 2001). p107 or Rb2/p130 can substitute pRb only if they are present in a sufficient amount to bind E2F1–3 proteins (Lee et al.,…”
- Pocket proteins and cell cycle control (2005, background): “For example, cyclin E was derepressed not only by loss of pRB but also by the combined loss of E2F1–3, suggesting that these E2Fs participate in a repressor complex (Wu et al., 2001).”
- The E2F family: specific functions and overlapping interests (2004, background): “Indeed, loss of all three activating E2Fs results in acute cell cycle arrest (Wu et al, 2001).”