Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

By S. Ishida, Erich Huang, H. Zuzan, Rainer Spang, Gustavo Leone, M. West, Joseph R. Nevins. Molecular and Cellular Biology, 2001

630 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ab69192f62fdcf8fbfa48535ffb08369d7cf7575

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Citations in the corpus

The retinoblastoma tumour suppressor in development and cancer (2002, background): “Although there is accumulating evidence that de-repression of E2F is important in both apoptosis and cell-cycle regulatio”
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. (2002, methodology): “Consistent with our findings, murine Rad51 was induced severalfold in cells ectopically expressing E2F1 or E2F2 (Ishida et al. 2001).”
Common markers of proliferation (2006, background): “E2F1 itself is also a member of the proliferation-associated gene-expression pattern, which indicates that transcription factors and their transcriptional targets are often co-regulated and therefore group together in a hierarchical clustering analysi”
GATHER: a systems approach to interpreting genomic signatures (2006, background): “First, GATHER has the capacity to discover novel functions of gene groups by integrating annotations from evolutionary homologs and other genes related through protein interaction or literature networks (Rual et al., 2005; Jenssen et al., 2001; Hoffmann and Valencia, 2004 ).”
Identification of genes periodically expressed in the human cell cycle and their expression in tumors. (2002, background): “…in a wide range of organisms, including budding yeast (Cho et al., 1998; Spellman et al., 1998), bacteria (Laub et al., 2000), primary human fibroblasts (Iyer et al., 1999; Cho et al., 2001), mouse fibroblasts (Ishida et al., 2001), and human HeLa cells (Crawford and PiwnicaWorms, 2001).”
The E2F1–3 transcription factors are essential for cellular proliferation (2001, result): “This view is consistent with recent genome-wide analyses of cell-cycle-regulated genes, where a large fraction of E2F-regulated gene targets were found to encode proteins known to be involved in the progression of cells into G2 and through mitosi”
Ki-67: more than a proliferation marker (2018, background): “We now know that the MKI67 gene promoter itself is cell cycle-regulated, containing binding sites for the canonical G1-regulatory E2F family of transcription factors (Ishida et al. 2001), and that Ki-67 mRNA levels increase during G1 (Sobecki et al. 2016, 2017).”
Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells. (2003, background): “This is in accordance with recent studies (Ishida et al. 2001; Polager et al. 2002) showing that E2F’s role in controlling the cell cycle goes beyond its previously documented control of the entry into the S phase.”