Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

By K. Moro, Taketo Yamada, M. Tanabe, T. Takeuchi, T. Ikawa, H. Kawamoto, J. Furusawa, M. Ohtani, H. Fujii, S. Koyasu. Nature, 2009

1,351 citations recorded by the source corpus.

Subfields: Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/ebb0f78aa9318dc03158670fe00ea7f73a7c175d

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In Immunology

1. D. Artis
2. A. Mantovani
3. C. Garlanda
4. H. Spits
5. R. Locksley
6. S. V. Van Dyken
7. Jinfang Zhu
8. W. E. Paul

In Surgery

1. D. Artis
2. Andrew N. J. McKenzie
3. H. Spits
4. R. Locksley
5. A. Mantovani
6. C. A. Dinarello
7. C. Garlanda

Citations in the corpus

• THE INTERLEUKIN-1 FAMILY: BACK TO THE FUTURE (2013, positive): “IL-33 plays a protective role against parasites ranging from nematode expulsion to control of Toxoplasma gondii encephalitis (Moro et al., 2010; Neill et al., 2010).”
• Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 (2011, background): “These cells have been variously called natural helper lymphocyte”
• Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes (2010, neutral): “RORgt is the lineage-defining transcription factor of LTi-like cells and is not expressed by any other of the recognized innate lymphocyte lineages (Moro et al., 2010).”
• The transcription factor GATA3 controls cell fate and maintenance of type 2 innate lymphoid cells (2012, positive): “Similar to the biological role of Th2 cells, ILC2s are involved in the defense against worm infections (Liang et al., 2012; Moro et al., 2010; Neill et al., 2010) and in tissue repair after influenza virus infection (Monticelli et al., 2011).”
• Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages (2013, background): “3 d), and these cytokines increased further with the ad dition of IL2 or IL7, similar to results reported by ILC2s from other tissues (Moro et al., 2010; Halim et al., 2012).”
• Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus (2011, background): “These cells are activated in response to the epithelial cell–derived cytokines IL-25 and/or IL-33 and can promote T H 2 cytokine–dependent protective immunity to helminth parasite”