Regulation of apoptosis by endoplasmic reticulum pathways

By D. Breckenridge, Marc Germain, Jaigi P. Mathai, M. Nguyen, G. Shore. Oncogene, 2003

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Mitochondria: In Sickness and in Health (2012, background): “Ca2+ release at ER-mitochondrial contacts may sensitize mitochondria to apoptotic effectors (Breckenridge et al., 2003; Iwasawa et al., 2011; Tabas and Ron, 2011).”
The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress (2016, background): “They are localized in the mitochondrial membrane and play a fundamental role in regulation of apoptotic cell death, since they are responsible for the activation of caspases [86, 87].”
Molecular mechanisms of resistance and toxicity associated with platinating agents. (2007, background): “This ER stress-induced apoptosis is dependent upon the activation of caspase-12 [19].”
Bcl-2 family proteins and cancer (2008, background): “…2001), Bcl-2 and Bcl-XL (which are inhibited), several caspases, and autophagy protein Atg5, which binds and inhibits Bcl-XL upon cleavage (reviewed by Breckenridge et al., 2003; Yousefi et al., 2006); and (j) death-associated kinase (DAP kinase) and its close relative DRP-1, which contain…”