The orphan receptor GPR55 is a novel cannabinoid receptor

By E. Ryberg, N. Larsson, S. Sjögren, S. Hjorth, Nils-Olov Hermansson, J. Leonova, T. Elebring, K. Nilsson, T. Drmota, P. Greasley. British Journal of Pharmacology, 2007

1,598 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/eb5cb6c89e89ea4df0d139f0b69bebf8711d7035

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In Molecular Biology

1. E. Denovan‐Wright
2. M. Kelly
3. Bertil Hille
4. R. Ross
5. A. Bagher
6. R. Laprairie
7. R. Pertwee
8. C. Dart

In Pharmacology

1. R. Pertwee
2. V. Di Marzo
3. George Kunos
4. R. Ross
5. R. Mechoulam
6. K. Mackie
7. Allyn C. Howlett
8. P. Greasley

Citations in the corpus

• GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current (2008, background): “(6) examined the role of GPR55 as a potential cannabinoid receptor, primarily by using GTP S binding.”
• Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor (2015, background): “, 2005), GPR55 (Ryberg et al., 2007), the μ- and δ-opioid receptors (Kathmann et al.”
• CB2: a cannabinoid receptor with an identity crisis (2010, background): “, 2000), but has since been shown to also be an agonist at GPR55 (Ryberg et al., 2007; Lauckner et al., 2008).”
• International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010, methodology): “This cannabinoid has been reported to display significant potency as an agonist at GPR55 with an EC50 of 8 nM in a [ (35)S]GTP S binding assay performed with HEK293 cells (Ryberg et al., 2007).”
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin (2008, background): “both anandamide and 2-arachidonoylglycerol can activate GPR55 (Ryberg et al., 2007) and modulate conductance in”
• Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications (2017, background): “An orphan receptor G-protein coupling, GPR55, has been as well shown to be stimulated by PEA as well as AEA by some authors (Ryberg et al., 2007), but not others (Kapur et al., 2009).”