The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin

By R. Pertwee. 2008

1,681 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Pharmacology, Plant Science

View Paper: https://www.semanticscholar.org/paper/2c58c8f9806995b9eeda1aecfb7e6177edcb9e8a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. R. Pertwee
2. V. Di Marzo
3. T. Winton-Brown
4. Shitij Kapur
5. Philip K. McGuire
6. K. Mackie
7. R. Ross
8. George Kunos

In Pharmacology

1. R. Pertwee
2. V. Di Marzo
3. George Kunos
4. R. Ross
5. R. Mechoulam
6. K. Mackie
7. Allyn C. Howlett
8. P. Greasley

In Plant Science

1. R. Pertwee
2. V. Di Marzo

Citations in the corpus

• International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010, background): “…nonclassical, aminoal-CANNABINOID RECEPTORS AND THEIR LIGANDS 591 a t A SP ET J ou r n a l s on F e b r u a r y 4 , 2024 ph a r m r e v . a s p e tj ou r n a l s . o r g D o w n l o a d e d fr o m kylindole, and eicosanoid (for review, see Pertwee, 1999, 2005a, 2008a,b; Howlett et al., 2002).”
• Antioxidative and Anti-Inflammatory Properties of Cannabidiol (2019, background): “Regardless of the effect on the CB1 receptor, CBD is a weak agonist of the CB2 receptor [64], but it has also been suggested that it may demonstrate inverse agonism of the CB2 receptor [65].”
• Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology (2010, background): “The widely distributed brain regions where D-9-THC and CBD had opposite effects is also consistent with the distribution of CB1 receptors in the brain (Elphick and Egertova, 2001) and evidence that they may have opposite effects on these receptors (Pertwee, 2008).”
• Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes (2011, background): “…(Mechoulam, 2000), and most of its effects are attributed to the activation of the cannabinoid CB1 and CB2 receptors, two G-protein-coupled receptors (GPCR) widely expressed in mammalian tissues (Matsuda et al., 1990; Munro et al., 1993; Van Sickle et al., 2005; Gong et al., 2006; Pertwee, 2008).”