Resetting of circadian time in peripheral tissues by glucocorticoid signaling.

By A. Balsalobre, S. Brown, Lysiane Marcacci, F. Tronche, C. Kellendonk, Holger M. Reichardt, G. Schütz, U. Schibler. Science, 2000

1,822 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Experimental and Cognitive Psychology, Physiology

View Paper: https://www.semanticscholar.org/paper/eb19ac70da8ab79fde9159573a207c67f67ead3a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. J. Takahashi
2. U. Schibler
3. C. H. Ko
4. U. Albrecht
5. C. Green
6. Ethan D. Buhr
7. J. Mohawk
8. C. Dibner

In Experimental and Cognitive Psychology

1. J. Takahashi

In Physiology

1. J. Takahashi
2. U. Schibler
3. U. Albrecht
4. C. Green
5. C. H. Ko
6. Ethan D. Buhr
7. C. Dibner
8. J. Mohawk

Citations in the corpus

• The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, background): “Dexamethasone synchronizes rat-1 fibroblasts and causes phase shifts in peripheral oscillators but does not affect SCN rhythms (250).”
• Glucocorticoid receptor signaling in health and disease (2013, background): “Moreover, glucocorticoids can reset the circadian rhythm in the peripheral tissues without the involvement of the master clock residing in the suprachiasmatic nucleus of the hypothalamus [109].”
• Extensive and divergent circadian gene expression in liver and heart (2002, methodology): “For each gene we required: (1) a positive correlation between the first and second days (selects for a daily repetition); (2) a negative autocorrelation at 12 h (removes ultradian oscillations and noise); (3) an amplitude threshold (removes trivial oscillations); and (4) a threshold for the maximum ”
• CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “The demonstration that dexamethasone (a glucocorticoid analog) could shift the phase of peripheral tissues in vivo (Balsalobre et al. 2000) provided the first definitive evidence that glucocorticoids were entraining signals for peripheral oscillators.”
• The circadian clock: pacemaker and tumour suppressor (2003, background): “Mammalian peripheral clocks do not respond directly to light stimuli, but are instead regulated by cyclic changes in the levels of neurotransmitters, growth factors, and hormones such as glucocorticoids and retinoid”
• Molecular components of the Mammalian circadian clock. (2013, background): “This food-induced resetting of peripheral oscillators is achieved, at least in part, by the ability of glucocorticoids in the circulatory system to control the phase of peripheral clocks (Damiola et al. 2000; Balsalobre et al. 2000).”
• Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. (2000, background): “Glucocorticoid hormones would be excellent candidates for such signals, as they cause phase shifts exclusively in peripheral cells types (Balsalobre et al. 2000a).”
• Circadian rhythms from multiple oscillators: lessons from diverse organisms (2005, background): “Furthermore, forskolin or corticosteroid treatment of fibroblast cell lines induces stable rhythms of core clock-gene mRNAs in vitro”
• The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “It is thought that circulating factors such as glucocorticoids and the circadian variation in body temperature might function as entraining signals for peripheral clock”
• Circadian Rhythms in Isolated Brain Regions (2002, background): “Furthermore, the identification of “clock genes” and the ability to measure their activity in cultured cells has led to the discovery that many non-neural tissues exhibit circadian modulations in molecular expression (Balsalobre et al., 1998, 2000; Yamazaki et al., 2000; Stokkan et al., 2001).”
• Timing to perfection: the biology of central and peripheral circadian clocks. (2012, background): “This is reminiscent of glucocorticoid or glucocorticoid analog synchronization of cell cultures (Balsalobre et al., 2000), with the difference being that they induce Per1 and Per2 gene expression that leads to a repression of their own transcription and subsequent synchronization of all cells within”
• Molecular components of the mammalian circadian clock. (2006, background): “This food-induced resetting of peripheral oscillators is achieved, at least in part, by the ability of glucocorticoids in the circulatory system to control the phase of peripheral clocks (Damiola et al. 2000; Balsalobre et al. 2000).”
• Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions (2006, neutral): “After synchronization of circadian gene expression by a dexamethasone shoc”
• A circadian clock in macrophages controls inflammatory immune responses (2009, background): “One candidate for a systemic timing signal—cortisol—is secreted in a circadian manner by the adrenal gland (10) and has been proposed to (i) drive circadian rhythms of cytokines and other immune functions (30) and (ii) to participate in the synchronization of peripheral oscillators (31).”