The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

By Christian Weber, A. Zernecke, Peter Libby. Nature reviews. Immunology, 2008

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Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans (2013, result): “Some mouse experiments provide support for earlier involvement of polymorphonuclear leukocytes in murine atherosclerosis (Drechsler et al., 2010; Weber et al., 2008).”
Monocyte recruitment during infection and inflammation (2011, background): “CCR5-mediated signals, for example, contribute to the pathogenesis of atherosclerosi”
Atherosclerosis: current pathogenesis and therapeutic options (2011, background): “Hypercholesterolemic apolipoprotein E–deficient ( Apoe −/− ) or LDL receptor–deficient ( Ldlr −/− ) mice are frequently used to study mechanisms of disease initiation and progression but are less suitable for investigations of advanced stages, such as plaque rupture or thrombosis, which continue t”
Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility (2010, background): “The study focused on peripheral blood monocytes because these cells may be isolated from an easily accessible tissue and play a key role in the pathogenesis of immune disorders and atherosclerosis-related diseases [18].”
Monocytes in atherosclerosis: subsets and functions (2010, background): “Initially, macrophages were reported as the predominant cell type present within atherosclerotic vessels, but T cells, B cells, neutrophils, mast cells, dendritic cells (DCs) and monocytes have all been observed in both mouse and human aortas”