β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

By P. McDonald, C. Chow, W. Miller, S. Laporte, M. Field, F. Lin, R. Davis, R. J. Lefkowitz. 2000

858 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eae2efb35663de9b300f49821d2740880003eecb

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In Cellular and Molecular Neuroscience

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Citations in the corpus

β-Arrestins and Cell Signaling (2007, background): “kinase kinase 4 (MKK4) and apoptosis signaling kinase (ASK1), were also present in the complex (74, 75).”
GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling (2006, background): “Indeed, apoptosis signal-regulating kinase 1 (a MAPKKK), MKK4 (a MAPKK) and JNK3 (a MAPK) are able to form a unique protein complex in association with b-arrestin [ 39 ].”
The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. (2002, positive): “The MAP kinase, JNK3, and possibly other MAP kinases (MAPKs), interact with β-arrestin 2 via a consensus MAP kinase recognition sequence, RRSLHL, located within the B domain.”
Seven-transmembrane-spanning receptors and heart function (2002, background): “2 ) is their role as adaptors or scaffolds that bring together elements of complex heptahelical-receptor-stimulated signalling pathways, and that facilitate the activation and subcellular localization of the signalling proteins involved in these pathway”
Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. (2002, background): “Recently, another scaffold for the Jnk pathway has been defined as β-arrestin 2, which binds the MAPKKK ASK1, the MAPKK MKK4, and Jnk3 (192).”
Mitogen-activated protein kinases in apoptosis regulation (2004, background): “Activation of JNK is also regulated by scaffold proteins such as JIP, b-arrestin, and JSAP1 (Whitmarsh et al., 1998; Ito et al., 1999; McDonald et al., 2000).”