Mitogen-activated protein kinases in apoptosis regulation

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Transforming Growth Factor- 1 to the Bone (2005, background): “Although knockout and transgenic mouse models of numerous MAPK signaling intermediates are available (81) (for mouse models with a bone phenotype, see Refs.”
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. (2006, background): “The role of MAPKs in cell death signalling pathways is not yet clear [209].”
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases (2007, background): “…signal transduction pathways, which are activated in response to a diverse array of extracellular stimuli and can mediate both physiological and pathological responses in mammalian cells and tissues (Chang and Karin, 2001; Pearson et al., 2001; Dong et al., 2002; Wada and Penninger, 2004).”