Cold-activated brown adipose tissue in healthy men.

By W. D. van Marken Lichtenbelt, Joost W. Vanhommerig, N. M. Smulders, Jamie Drossaerts, Gerrit J. Kemerink, N. D. Bouvy, Patrick Schrauwen, G. J. J. Teule. New England Journal of Medicine, 2009

3,302 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/ea3c49846fca44a06e4ccfcbb6eface1c5755bf8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. P. Calder
2. R. Zechner
3. B. Spiegelman
4. Mitchell A. Lazar
5. M. Rogero
6. Ana G. Cristancho

In Epidemiology

1. B. Spiegelman
2. Beth Levine
3. N. Mizushima
4. S. Kajimura
5. Mitchell A. Lazar
6. José Fernández-Real
7. F. Tinahones
8. P. Calder

In Physiology

1. S. Kajimura
2. B. Spiegelman
3. Beth Levine
4. N. Mizushima
5. Jun Wu
6. P. Cohen
7. Mitchell A. Lazar
8. J. Heeren

Citations in the corpus

• Mitochondria: In Sickness and in Health (2012, background): “…discovery of active brown adipose tissue in adult humans has opened up an intriguing avenue in obesity research by clarifying the role of adaptive thermogenesis in counteracting fat storage through UCP1-mediated mitochondrial uncoupling (van Marken Lichtenbelt et al., 2009; Virtanen et al., 2009).”
• Mitochondrial proton and electron leaks (2010, background): “Two recent fi ndings focus major interest on brown adipose tissue as a target for obesity treatment: (i) the presence of UCP1 in mice prevents obesity even at thermoneutrality, and (ii) the identifi cation of functional brown adipose tissue in adult humans [46–49].”
• Brown adipose tissue activity controls triglyceride clearance (2011, background): “and has recently been shown to be present in human”
• Forming functional fat: a growing understanding of adipocyte differentiation (2011, background): “For many years, BAT was thought to be absent in human adults, but recent fluorodeoxyglucose positron emission tomography studies of normal humans have identified regions of high glucose uptake that represent metabolically active tissu”
• A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. (2014, background): “The induction of brown adipocytes in WAT depots of humans (Cypess et al., 2009; van Marken Lichtenbelt et al., 2009; Virtanen et al., 2009) has been shown recently to significantly affect overall energy balance (Yoneshiro et al., 2013).”
• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “Several recent reviews have summarized studies of UCP1-positive cells in humans (Enerback 2010a; van Marken Lichtenbelt and Schrauwen 2011).”
• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells (2012, background): “humans have significant amounts of active brown fat deposits [3,4,5,6,7,8,9].”