Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition

By Hui Yang, Chaojie Liu, Dan-feng Yang, Hua-shan Zhang, Zhuge Xi. Journal of Applied Toxicology, 2009

1,074 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Materials Chemistry, Pollution

View Paper: https://www.semanticscholar.org/paper/91af08adb8d8044a521461e884bfa2c145be5dfc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. K. S. Siddiqi
2. O. Farokhzad
3. G. Xing
4. Azamal Husen

In Materials Chemistry

1. Diana Anderson
2. Vyom Sharma
3. A. Dhawan
4. K. S. Siddiqi
5. O. Farokhzad
6. G. Xing
7. Azamal Husen

In Pollution

1. Diana Anderson
2. Vyom Sharma
3. A. Dhawan

Citations in the corpus

• Cytotoxicity and genotoxicity of silver nanoparticles in human cells. (2009, background): “ROS-mediated genotoxicity has been previously observed for metal oxide nanoparticles.(28) This is the first”
• Nanomaterial cytotoxicity is composition, size, and cell type dependent (2010, background): “reduced product in culture medium and because MWCNT interfere with the MTT reduction assay [46,47].”
• Prevalence of exposure of heavy metals and their impact on health consequences (2018, background): “Investigations were also conducted on other nanoparticles which summarizes that the key role player is oxidative stress.(252) A study was conducted by Zhao et al(253) on mouse.”
• Genotoxic effects of zinc oxide and titanium dioxide nanoparticles on root meristem cells of Allium cepa by comet assay (2014, background): “This occurred when this nanomaterial was tested using different mammalian cell line models such as primary mouse embryo fibroblasts (Yang et al., 2009), human epidermal (A431) cells (Sharma et al.”
• The Toxic Effects and Mechanisms of CuO and ZnO Nanoparticles (2012, background): “Meanwhile, with increased ROS production, NPs can cause DNA damage and increase gene expression of the death receptor [107].”
• Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes (2018, background): “[95] have investigated the cytotoxicity, genotoxicity, and oxidative stress of zinc oxide nanoparticles on primary mouse embryo fibroblast cells.”
• Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2) (2012, background): “This observation is consistent with the earlier studies which have shown similar effects on primary mouse embryo fibroblast cells and human lymphoblastoid cells (WIL2-NS) [12, 36].”
• Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. (2011, background): “The pro-inflammatory properties of different nanomaterials have been reported previously, often linked with the ability to induce oxidative stres”
• Zinc Oxide Nanoparticles for Selective Destruction of Tumor Cells and Potential for Drug Delivery Applications (2010, background): “However, for nanoscale ZnO, large numbers of valence band holes and/or conduction band electrons are thought to be available to serve in redox reactions even in the absence of UV light [51].”