The Toxic Effects and Mechanisms of CuO and ZnO Nanoparticles

By Ya-nan Chang, Mingyi Zhang, Lin Xia, Jun Zhang, G. Xing. Materials, 2012

747 citations recorded by the source corpus.

Recent nanotechnological advances suggest that metal oxide nanoparticles (NPs) have been expected to be used in various fields, ranging from catalysis and opto-electronic materials to sensors, environmental remediation, and biomedicine. However, the growing use of NPs has led to their release into environment and the toxicity of metal oxide NPs on organisms has become a concern to both the public and scientists. Unfortunately, there are still widespread controversies and ambiguities with respect to the toxic effects and mechanisms of metal oxide NPs. Comprehensive understanding of their toxic effect is necessary to safely expand their use. In this review, we use CuO and ZnO NPs as examples to discuss how key factors such as size, surface characteristics, dissolution, and exposure routes mediate toxic effects, and we describe corresponding mechanisms, including oxidative stress, coordination effects and non-homeostasis effects.

Subfields: Electronic, Optical and Magnetic Materials, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/31f34c879427aa977f9fc0ab00ed08e36f3bb591

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Electronic, Optical and Magnetic Materials

1. Atish Patel
2. Jingran Lu
3. Zhe-Sheng Chen
4. Huizhong Xu
5. Liuya Wei
6. Guofang Chen

In Materials Chemistry

1. Atish Patel
2. Jingran Lu
3. Zhe-Sheng Chen
4. Huizhong Xu
5. Liuya Wei
6. Guofang Chen

Citations in the corpus

• CuO nanoparticles significantly influence in vitro culture, steviol glycosides, and antioxidant activities of Stevia rebaudiana Bertoni (2017, background): “The reactivity and toxicity of metallic oxide NPs depend on their size, surface, structure, concentration, dissolution and exposure routes (Franklin et al. 2007; Jiang et al. 2009; Chang et al. 2012).”
• Metal-Based Nanoparticles as Antimicrobial Agents: An Overview (2020, background): “They penetrate cells via ion channels and biological pumps and when they exceed tolerable range, toxic effects occur [188].”
• Silver nanoparticles: synthesis, properties, and therapeutic applications (2014, background): “Nanoparticles can induce reactive oxygen species (ROS) production directly once they are exposed to the acidic environment of lysosomes [42].”