Zinc Oxide Nanoparticles for Selective Destruction of Tumor Cells and Potential for Drug Delivery Applications

By John W. Rasmussen, E. Martínez, Panagiota Louka, D. Wingett. Expert Opinion on Drug Delivery, 2010

1,248 citations recorded by the source corpus.

Importance of the field: Metal oxide nanoparticles, including zinc oxide, are versatile platforms for biomedical applications and therapeutic intervention. There is an urgent need to develop new classes of anticancer agents, and recent studies demonstrate that ZnO nanomaterials hold considerable promise. Areas covered in this review: This review analyzes the biomedical applications of metal oxide and ZnO nanomaterials under development at the experimental, preclinical and clinical levels. A discussion regarding the advantages, approaches and limitations surrounding the use of metal oxide nanoparticles for cancer applications and drug delivery is presented. The scope of this article is focused on ZnO, and other metal oxide nanomaterial systems, and their proposed mechanisms of cytotoxic action, as well as current approaches to improve their targeting and cytotoxicity against cancer cells. What the reader will gain: This review aims to give an overview of ZnO nanomaterials in biomedical applications. Take home message: Through a better understanding of the mechanisms of action and cellular consequences resulting from nanoparticles interactions with cells, the inherent toxicity and selectivity of ZnO nanoparticles against cancer may be improved further to make them attractive new anticancer agents.

Subfields: Biomaterials, Materials Chemistry, Oncology

View Paper: https://www.semanticscholar.org/paper/a516e3c8241482a62128b20d0ad5e0277a7c27ea

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In Biomaterials

1. P. Mahanwar

In Materials Chemistry

1. Diana Anderson
2. Vyom Sharma
3. A. Dhawan
4. S. K. M. Bakhori
5. Habsah Hasan
6. S. Mahmud
7. N. Amor
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Citations in the corpus

• Zinc Oxide Nanoparticles for Revolutionizing Agriculture: Synthesis and Applications (2014, background): “Some studies have indicated that ZnO NPs affected functions of different cells or tissues, biocompatibility, and neural tissue engineering [6, 33, 34] but little information is present about the influence on CNS and CNS related diseases.”
• The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications (2018, background): “ZnO NPs are listed as a kind of safe substance by the FDA.”
• Synthesis and applications of ZnO nanostructures (ZONSs): a review (2021, background): “US Food and Drug Administration (FDA) graded ZnO as a safe material.([66]) Due to easily availability, nontoxicity and less”
• Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2) (2012, background): “This produces highly reactive free radicals including the superoxide anion radical (from electrons) and the hydroxyl radical (from holes) [5].”
• Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism (2015, background): “These modified features allow the NPs to interact in a unique manner with cell biomolecules and thus facilitate the physical transfer of NPs into the inner cellular structures [6].”