Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation.

By Zhou J. Deng, Mingtao Liang, M. Monteiro, I. Toth, R. Minchin. Nature Nanotechnology, 2011

835 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The effect of nanoparticle size, shape, and surface chemistry on biological systems. (2012, background): “The denatured fibrinogen can then bind to the integrin receptor Mac-1 and lead to inflammation (10).”
Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle (2013, background): “Gold (7-22 nm) Human Fibrinogen 340 kDa 45 × 5 Yes CD Unfolding induced immune response in THP-1 cells [35]”
Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake. (2015, background): “patches of positive charge at either end of the rod, through which it may adsorb onto the negatively charged NPs.(92) FIB is known to be quite flexible, and”
Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. (2014, background): “Surface-adsorbed serum proteins may either promote cell association or inhibit it.(26,58) The sign of the bi coefficients from the model (eq 2) reflects the correlation between each adsorbed serum protein and cell association.”