dunce, a mutant of Drosophila deficient in learning.

By Y. Dudai, Y. Jan, D. Byers, W. G. Quinn, S. Benzer. 1976

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “Two memory processes that are thought to rely on different molecular and circuit mechanisms, anesthesia resistant memory and anesthesia sensitive memory, contribute to memory at this retention time (Dudai et al., 1976; Folkers et al., 1993; Isabel et al., 2004; Krashes and Waddell, 2008; Aso et al.,”
Classical conditioning and retention in normal and mutantDrosophila melanogaster (1985, background): “The mutants dunce I (Dudai et al. 1976) and rutabaga PsSH (Aceves-Pina and Quinn 1979) were isolated in the original olfactory shock-avoidance test (Quinn et al.”
Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation (2012, unknown): “relevant genes dunce, rutabaga, gilgamesh and derailed (Dudai et al., 1976; Tully and Quinn, 1985; Tan et al., 2010; Moreau-Fauvarque et al., 2002) as well as in the transmitter receptor genes nAcRalpha80B and GABA-B-R1 and the cAMP signaling relevant Gprk1 and cngl genes.”
Odorant-induced oscillations in the mushroom bodies of the locust (1994, background): “The reduced expression of these genes in Drosophila mutants leads to the deficits in associative olfactory learning that were originally exploited for genetic dissection (see Dudai et al., 1976; Dudai, 1988).”
Identifying behavioral circuits in Drosophila melanogaster: moving targets in a flying insect. (2012, background): “Over the next decade, mutants that were defective for many behaviors, including learning [1], male courtship [2] and circadian rhythms [3], were isolated.”
Genetic manipulation of genes and cells in the nervous system of the fruit fly (2011, background): “, 1971), diurnal rhythmicity (Konopka and Benzer, 1971), learning and memory (Dudai et al., 1976), and sleep (Cirelli, 2003).”
Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory. (2015, background): “In particular, the phosphodiesterase-encoding dunce (dnc) gene, one of the first memory genes identified inDrosophila (Dudai et al., 1976), underlies 3-hr ARM, that we here named MT-ARM (Scheunemann et al.”
Flies, genes, and learning. (2001, methodology): “The first olfactory learning mutant identified in this paradigm, by Byers in Benzer’s lab, wasdunce(Dudai et al 1976).dunceflies learn very poorly in the olfactory paradigm, although they can sense odorants and shock and they appear normal in other behaviors.”
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB (2012, background): “Moreover, flies with these mutations do not respond to either classical conditioning of fear or to sensitization, suggesting that – as in Aplysia – the two types of learning have some genes in common [8,12].”
Operant conditioning in invertebrates. (2003, background): “Heat-box learning in Drosophila Research on the genetically renowned fruit fly Drosophila (Figure 1a) has been revealing a steady flow of genes that are involved in olfactory classical conditioning for the past three decades [3–11].”
The molecular and systems biology of memory. (2014, unknown): “From 1964 to 1979, several simple model systems of implicit memory emerged: the flexion reflex of cats, the eye-blink response of rabbits, and a variety of simple forms of reflex learning in invertebrates: namely, the defensive gill-withdrawal reflex of Aplysia, olfactory learning in Drosophila, the”
Modelling learning and memory in Drosophila to understand Intellectual Disabilities. (2020, unknown): “This test allowed the identification of the first learning and memory Drosophila mutants in the field, dunce, rutabaga, amnesiac, and turnip (Dudai et al., 1976; Aceves-Pina and Quinn, 1979; Quinn et al., 1979; Livingstone et al., 1984).”
Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression (2016, unknown): “…>100 genes in memory formation (Aceves-Pina and Quinn, 1979; Boynton and Tully, 1992; Comas et al., 2004; Didelot et al., 2006; Dubnau et al., 2003; Dudai et al., 1976; Dura et al., 1993; Heisenberg et al., 1985; Quinn et al., 1979; Skoulakis and Davis, 1996; Tomchik and Davis, 2013; Walkinshaw et…”
Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant. (1984, methodology): “…of the mutations, such as the dunce female sterility, these mutants are all behaviorally normal except in tests that look at behavioral plasticity (Dudai et al., 1976; Wright et al., 1982; Quinn et al., 1979; Byers et al., 1981; Duerr and Quinn, 1982; Livingstone and Tempel, 1982; Aceves-Pifia et…”
Genetic dissection of consolidated memory in Drosophila. (1994, background): “Behavior-genetic analyses of the “learning” mutants dunce and rutabaga (Dudai et al., 1976; Livingstone et al., 1984) have revealed that single-gene mutations can disrupt associative learning, but even null alleles of these genes do not block learning entirely (Tully and Quinn, 1985; Tully and Gold,”