Modelling learning and memory in Drosophila to understand Intellectual Disabilities.
By V. Mariano, Tilmann Achsel, C. Bagni, Alexandros K. Kanellopoulos. 2020
44 citations recorded by the source corpus.
Neurodevelopmental disorders (NDDs) include a large number of conditions such as Fragile X syndrome, Autism Spectrum Disorders and Down Syndrome, among others. They are characterized by limitations in adaptive and social behaviors, as well as intellectual disability (ID). Whole-exome and whole-genome sequencing studies have highlighted a large number of NDD/ID risk genes. To dissect the genetic causes and underlying biological pathways, in vivo experimental validation of the effects of these mutations is needed. The fruit fly, Drosophila melanogaster, is an ideal model to study NDDs, with highly tractable genetics, combined with simple behavioral and circuit assays, permitting rapid medium-throughput screening of NDD/ID risk genes. Here, we review studies where the use of well-established assays to study mechanisms of learning and memory in Drosophila has permitted insights into molecular mechanisms underlying IDs. We discuss how technologies in the fly model, combined with a high degree of molecular and physiological conservation between flies and mammals, highlight the Drosophila system as an ideal model to study neurodevelopmental disorders, from genetics to behavior.
Subfields: Aging, Genetics, Molecular Biology
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Citations in the corpus
- Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila (2022, background): “, 2021; Waddell and Quinn, 2001) as well as related human diseases (Mariano et al., 2020; Pandey and Nichols, 2011; van Alphen and van Swinderen, 2013).”