Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant.

By Margaret S. Livingstone, P. P. Sziber, W. G. Quinn. 1984

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Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “DOI: 10.7554/eLife.04580 3 of 42 Research article cyclase encoded by the rutabaga gene, are required specifically in the KCs for memory formation (Livingstone et al., 1984; Zars et al., 2000; Schwaerzel et al., 2003; Kim et al., 2007; McGuire et al., 2003; Gervasi et al., 2010; Qin et al., 2012)…”
Classical conditioning and retention in normal and mutantDrosophila melanogaster (1985, methodology): “More interestingly, the double learning mutant dnc TM 1, rut, which has roughly compensating biochemical deficiencies and near-normal cAMP levels ( Livingstone et al. 1984 ), learns much more poorly than either single mutant.”
Short and Long-term memory in Drosophila require cAMP signaling in distinct neuron types (2009, background): “RUTABAGA Adenylyl Cyclase Is Required for Short- and Long-Term Memory As previously reported [23, 30 , 31], each of two rutabaga mutant alleles exhibited severely reduced performance 2 min as well as 3 hr after a single aversive Pavlovian training session (Figure 1A; see also below).”
Odorant-induced oscillations in the mushroom bodies of the locust (1994, background): “…mushroom bodies (or corpora pedunculata, a bilaterally symmetrical neuropil of the protocerebrum) as the dominant site of expression of several metabolic enzymes in the CAMP pathway in the brain (Livingstone et al., 1984; Nighorn et al., 199 1; Han et al., 1992; Levin et al., 1992; Davis, 1993).”
Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning (2019, background): “cAMP was maximally evoked when KC and DAN stimulation were synchronous, matching the timing that gave rise to the strongest depression of KC-MBON signaling (Figures 2E and 5E) and consistent with evidence that calcium-sensitive adenylate cyclases serve as molecular coincidence detectors to amplify c”
Drosophila olfactory memory: single genes to complex neural circuits (2007, background): “, and rutabaga ( rut ), encoding a type I Ca 2+ /calmodulin-stimulated adenylyl cyclas”
Mushroom body memoir: from maps to models (2003, background): “, which has been considered to be the molecular site of convergence of the US and CS pathways in associative learnin”
A connectome of a learning and memory center in the adult Drosophila brain (2017, background): “…1 p e d c > α /β (2 ) α lobe DPM APL dependent adenylate cyclase rutabaga, which initiates a cAMP signaling cascade that leads to the biochemical changes underlying synaptic plasticity (Livingstone et al., 1984; Levin et al., 1992; Boto et al., 2014; Gervasi et al., 2010; Tomchik and Davis, 2009).”
The molecular and systems biology of memory. (2014, unknown): “…Dudai, Quinn, and Livingstone found that in several lines of Drosophila, the mutant genes represent one or another component of the cAMP pathway (Byers et al., 1981; Dudai et al., 1983; Livingstone et al., 1984), the same pathway that underlies sensitization and classical conditioning in Aplysia.”
High-Resolution Analysis of Ethanol-Induced Locomotor Stimulation in Drosophila (2002, background): “gene a calcium/calmodulin-sensitive adenylyl cyclase (Livingstone et al., 1984; Levin et al., 1992).”