The DNA replication checkpoint response stabilizes stalled replication forks

By Massimo Lopes, Cecilia Cotta-Ramusino, A. Pellicioli, Giordano Liberi, P. Plevani, M. Muzi-Falconi, C. Newlon, M. Foiani. Nature, 2001

807 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e9ac879ee3e08577360d56229078e8c6932e2613

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Citations in the corpus

Surviving the breakup: the DNA damage checkpoint. (2006, background): “DSB: double-strand DNA break checkpoint function (33, 164), and the essential role of Mec1 and Rad53 during normal cell growth appears to be in stabilizing stalled replication forks (84, 138).”
Maintaining genome stability at the replication fork (2010, background): “The ATR (Mec1 in yeast) pathway is activated by stalled RFs with exposed ssDNA regions coated with replication protein A (RPA), and they have a central role in promoting RF stabilization and DNA repai”
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex (2003, background): “This is particularly important in S phase of the cell cycle, when genomic DNA is most susceptible to various environmental hazard”
Recombination proteins in yeast. (2004, background): “coli (170), but in yeast, regressed forks have only been observed in hydroxyurea (HU)-arrested cells in the absence of the S-phase checkpoint kinase Rad53 (111).”
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair (2005, neutral): “dtd" [ ]> The essential checkpoint kinase Chk1 is required for cell-cycle delays after DNA damage or blocked DNA replicatio”
Toward maintaining the genome: DNA damage and replication checkpoints. (2002, background): “The roles of Mec1 and Rad53 proteins in preventing catastrophic termination of forks are likely crucial (48, 119, 188).”
PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination (2009, background): “In yeast, HU-induced fork stalling is reversible and forks only collapse in certain back- grounds, for example rad53 mutants (Lopes et al, 2001); it is only in those backgrounds that HR is triggered for repair (Meister et al, 2005).”