S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

By Y. Katou, Yutaka Kanoh, M. Bando, H. Noguchi, Hirokazu Tanaka, T. Ashikari, K. Sugimoto, K. Shirahige. Nature, 2003

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Cohesin: its roles and mechanisms. (2009, background): “The second group includes Mrc1 (also associated with replication forks) (73) and a Replication Factor C (RFC) complex, whose Ctf1 subunit has been replaced by the Ctf1-like protein Ctf18 and contains the additional subunits Dcc1 and Ctf8 (104).”
Cohesin relocation from sites of chromosomal loading to places of convergent transcription (2004, methodology): “We analysed cohesin binding to chromosome VI of the budding yeast Saccharomyces cerevisiae by chromatin immunoprecipitation (ChIP) followed by hybridization to a high-density oligonucleotide arra”
Maintaining genome stability at the replication fork (2010, background): “cerevisiae , proteins such as Mrc1 and Tof1 limit progression of the replisome under such circumstance”
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks (2006, background): “Previous studies have shown that Mrc1 and Tof1 are recruited to origins during initiation and then move with the forks as part of the replisom”
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. (2005, background): “Consistent with this, CHIP studies show also that uncoupling of Cdc45 and RPA from DNA synthesis is minimal in wild-type yeast cells treated with HU (Katou et al. 2003).”