Toward a neurobiology of obsessive-compulsive disorder.

By Ann M. Graybiel, Scott L. Rauch. Neuron, 2000

795 citations recorded by the source corpus.

Subfields: Clinical Psychology, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/e96f35819d75ef27ef48d343d4bb51bc0f342d29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Psychology

1. John P. O'Doherty
2. E. Bullmore
3. Samuel R. Chamberlain
4. Trevor W. Robbins
5. Naomi A. Fineberg
6. Barbara J. Sahakian
7. Israel Liberzon
8. Ann M. Graybiel

In Cognitive Neuroscience

1. Trevor W. Robbins
2. John P. O'Doherty
3. E. Bullmore
4. Bernard W. Balleine
5. Ann M. Graybiel
6. Samuel R. Chamberlain
7. Naomi A. Fineberg
8. Peter S. Dayan

Citations in the corpus

• Postsynaptic endocannabinoid release is critical to long-term depression in the striatum (2002, background): “, dysregulation of corticostriatal neurotransmission may be involved in compulsive behavioral disorder”
• The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “One neurocircuitry model of OCD posits that the striatum (caudate nucleus) functions abnormally, leading to inefficient gating in the thalamus (Graybiel and Rauch, 2000; Rauch et al, 1998a).”
• The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. (2005, positive): “The neurochemistry of OCD is nonetheless not well characterised (Graybiel and Rauch, 2000), and importantly 40–60% of OCD sufferers do not respond to appropriate courses of SRI treatment (Kaplan and Hollander, 2003; Davidson and Bjorgvinsson, 2003).”
• Habits, rituals, and the evaluative brain. (2008, background): “Helpful as habits can be in daily life, they can become dominant and intrusive in neuropsychiatric disorders, including obsessive-compulsive disorder (OCD), Tourette syndrome, and other so-called OC-spectrum disorders (Albin & Mink 2006, Graybiel & Rauch 2000, Leckman & Riddle 2000).”
• A specific role for posterior dorsolateral striatum in human habit learning (2009, background): “…for research into the etiology and treatment of a range of human neuropsychiatric diseases thought to involve impairments in habitual control, such as drug addiction, pathological gambling and obsessive–compulsive disorder (Graybiel & Rauch, 2000; Goudriaan et al., 2004; Everitt & Robbins, 2005).”
• Striatal plasticity and basal ganglia circuit function (2008, background): “…such as Tourette’s syndrome (TS) and trichotillomania (hair-pulling) are psychiatric disorders characterized by repetitive thought patterns (obsessions) and uncontrollable urges (compulsions) to perform motor routines (rituals), often directed at easing obsessions (Graybiel and Rauch, 2000).”
• Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. (2008, background): “The current dominant model of OCD focuses on abnormalities in cortico-striatal circuitry, with particular emphasis on the orbitofronto-striato-thalamic circuits (Saxena et al., 1998, 2001a; Graybiel and Rauch, 2000).”