Postsynaptic endocannabinoid release is critical to long-term depression in the striatum

By Gregory L. Gerdeman, J. Ronesi, D. Lovinger. Nature Neuroscience, 2002

741 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/2d1914856b6cfb4065b2aa27240b36a0c0f44ae4

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Citations in the corpus

Long-term depression in the CNS (2010, background): “Endocannabinoids can also function as retrograde messengers in the striatu”
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “…of LTD that required endocannabinoids, (so-called endocannabinoid-mediated LTD; eCB-LTD) was observed in the glutamatergic synapses onto medium spiny neurons in the striatum as well as at synapses between layer V pyramidal neurons (Gerdeman et al, 2002; Robbe et al, 2002a; Sjostrom et al, 2003).”
FOXP2 as a molecular window into speech and language. (2009, background): “High-frequency stimulation of glutamatergic synapses in the striatum normally induces robust long-term depression, a form of long-term plasticity, which dependson endocannabinoidretrogradesignalling and has important roles in striatal-dependent learning [ 54 ,55].”
The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “…modulate both inhibitory GABAergic and excitatory glutamatergic transmissions via multiple mechanisms (Marsicano and Lutz, 1999; Alger, 2002, 2004; Gerdeman et al., 2002; Robbe et al., 2002; Azad et al., 2003; Freund et al., 2003; Gerdeman and Lovinger, 2003; Kim and Alger, 2004; Isokawa and…”
Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill (2009, methodology): “Whole-cell recordings were carried out as previously describe”
Striatal plasticity and basal ganglia circuit function (2008, background): “…striatal LTD requires dopamine D2 receptors, Gq-coupled group I mGluRs, L-type calcium channels, and CB1 receptor activation, but notably, not NMDA receptors or mAChRs (Calabresi et al., 1992a, 1997; Choi and Lovinger, 1997; Gerdeman et al., 2002; Kreitzer and Malenka, 2005; Sung et al., 2001).”
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance (2014, methodology): “the commonly used HFS-LTD protocol in which stronger depolarization to −15 mV (37) favors the activation of voltage-gated calcium channels (38, 39).”
Endocannabinoid signaling as a synaptic circuit breaker in neurological disease (2008, background): “The first discovery that long-term depression of central synapses is also mediated by retrograde endocannabinoid signaling was made in the dorsal striatu”
Modulation of striatal projection systems by dopamine (2011, neutral): “The induction of LTD requires the postsynaptic generation of endocannabinoids (ECs) (Gerdeman et al., 2002).”
Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability. (2003, neutral): “…the hippocampus (Kreitzer and Regehr, 2002; Wilson (B) When bath applied 20 min after I-LTD induction, AM251 had noand Nicoll, 2002) and could mediate LTD at excitatory effect on IPSCs amplitude or PPR (n 5). synapses in striatum and nucleus accumbens (Gerdeman et al., 2002; Robbe et al., 2002).”
Distinct coincidence detectors govern the corticostriatal spike timing‐dependent plasticity (2010, background): “2005, 2008), striatum (Gerdeman et al. 2002; Robbe et al. 2002; Kreitzer & Malenka, 2005; Lafourcade et al. 2007; Narushima et al. 2007) or cerebellum (Maejima et al.”