Directional Sensing Requires G-Mediated PAK1 and PIX-Dependent Activation of Cdc42

By Zhong Li, Michael O. Hannigan, Zhicheng Mo, Bo Liu, Yue Wu, A. Smrcka, Guan-qing Wu, Mingyao Liu, Chi‐Kuang Huang, Dianqing Wu. 2003

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Rho GTPases: biochemistry and biology. (2005, background): “Recent work in neutrophils suggests that this involves the localization of α-PIX, a Racspecific GEF, through an unexpected pathway in which the Cdc42 target, PAK, acts as a scaffold rather than a kinase (Li et al. 2003).”
Cdc42 - the centre of polarity (2004, background): “An alternative pathway leading to Cdc42 activation is induced by heterotrimeric G protein signalling during neutrophil responses to the chemoattractant C5a, which acts through serpentine receptors (Li et al., 2003) (Fig.”
Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool‐2/α‐Pix (2004, background): “While chemoattractants activate Rac in human neutrophils (Benard et al, 1999), it is not clear that Cool-2 is essential for chemoattractant-dependent Rac activation (Li et al, 2003).”
Signaling in innate immunity and inflammation. (2012, background): “It is recruited to Gbg via the kinase PAK1 and appears to function by interacting with the GTPase Cdc42 and the GTPase-activating (GAP) protein GIT2 (Li et al. 2003; Mazaki et al. 2006).”