SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

By E. Michishita, R. McCord, Elisabeth Berber, M. Kioi, H. Padilla-Nash, M. Damian, Peggie Cheung, Rika Kusumoto, Tiara L. A. Kawahara, J. Barrett and 5 more. Nature, 2008

1,102 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e93e298451cb0d965e8933da9a3ab04e44f65ff0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Johan Auwerx
2. E. Verdin
3. C. Cantó
4. R. Houtkooper
5. M. Haigis
6. E. Seto
7. R. Mostoslavsky
8. T. Arnesen

In Molecular Biology

1. Aviv Regev
2. E. Verdin
3. Minoru Yoshida
4. Johan Auwerx
5. E. Seto
6. Amir Goren
7. R. Houtkooper
8. Orian Shirihai

In Physiology

1. Johan Auwerx
2. C. Cantó
3. E. Verdin
4. R. Houtkooper
5. E. Seto
6. E. Pirinen
7. Orian Shirihai
8. Aviv Regev

Citations in the corpus

• Sirtuins as regulators of metabolism and healthspan (2012, background): “18 ) were reported to function as ADP-ribosyltransferases , even though SIRT6 also can act as a deacetylas”
• Stability and kinetics of G-quadruplex structures (2008, background): “However, the telomeres are normally bound up in histones (274,275), even if the linker histone distribution differs somewhat from ‘average’ DNA, and are regulated by acetylation and deacetylation (274,276).”
• Sirtuin Regulation of Mitochondria - Energy Production, Apoptosis, and Signaling (2010, background): “Yang B, et al. The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability.”
• The world of protein acetylation. (2016, background): “Normally, this cytosolic sirtuin will deacetylate H3K9ac [428] and H3K56ac [429, 430], which normally contribute to telomere integrity and help avoid premature senescence [428].”
• The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, positive): “SIRT6 / mice die prematurely, displaying severe defects, such as lymphopenia, loss of sc fat, decreased bone mineral density, a profound imbalance in glucose homeostasis, and decreased IGF-I levels (124).”
• Erasers of histone acetylation: the histone deacetylase enzymes. (2014, background): “Later studies, however, reveal that SIRT6 deacetylates H3K9 and H3K56 (e.g., Michishita et al. 2008), although biochemical and structural analyses argue that SIRT6 has very low deacetylase activity compared to other sirtuins.”
• The Histone Deacetylase SIRT6 Regulates Glucose Homeostasis via Hif1α (2010, positive): “, 2006), and the fact that SIRT6 is known to function as a histone H3K9 deacetylase (Kawahara et al., 2009; Michishita et al., 2008), we hypothesized that SIRT6 could influence glucose metabolism by controlling expression of key metabolic genes.”