Central nervous system control of food intake and body weight

By G. Morton, D. Cummings, D. Baskin, G. Barsh, M. Schwartz. Nature, 2006

2,480 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/e91a64e7bbba35408374ad1295546c46df05d853

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In Endocrine and Autonomic Systems

In Nutrition and Dietetics

In Physiology

Citations in the corpus

Human gut microbiota in obesity and after gastric bypass (2009, background): “Although an increased intake of energy-dense foods, especially when combined with reduced physical activity, surely contributes to the high prevalence of obesity, the existence of complex systems that regulate energy balance requires that this paradigm be considered in a larger context (1).”
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. (2011, background): “Alteration in energy balance is the main determinant of body composition and body weight, and is coordinated by central nervous system (CNS) pathways, including the central melanocortin system (Cone, 2005; Cone, 2006; Morton et al., 2006).”
The Pathophysiology of Gestational Diabetes Mellitus (2018, neutral): “, satiety and hunger hormones) signals [87,88].”
A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping (2008, methodology): “POMC and agouti-related protein (AGRP) gene expression each define separate neuron populations intermingled in the ARC, which, respectively, inhibit and stimulate feeding (Morton et al., 2006).”
Dynamic Energy Budget Theory for Metabolic Organisation (2005, background): “Food-searching behaviour is then subjected to regulation processes in the sense that an animal eats what it needs; the nervous system plays an important role in this regulation [811].”
Malnutrition in Older Adults—Recent Advances and Remaining Challenges (2021, background): “Last but not least, in the case of reduced smell and taste, the reward system in the central nervous system (CNS) is hampered in the perception of pleasure associated with palatable foods [109] which may in turn further decrease dietary intake.”
Pharmacological management of obesity: an endocrine Society clinical practice guideline. (2015, background): “GLP-1 agonists also affect the POMC neurons and cause satiety (18).”
Physiology of Astroglia. (2018, neutral): “These hypothalamic structures integrate numerous signals including major metabolites (glucose, free fatty acids, and amino acids) as well as dedicated hormones (leptin, ghrelin and insulin) and regulate appetite and food intake, deposition of fat, and energy expenditure (1157).”
The many faces of insulin-like peptide signalling in the brain (2012, background): “Insulin regulates energy homeostasis by modulating the intertwined carbohydrate and lipid metabolic pathway”
Insulin and insulin-like growth factor signalling in neoplasia (2008, background): “It is of interest that, whereas AMPK and mTOR signalling systems regulate cellular behaviour in response to nutrient availability, in higher organisms these same systems are used by specialized cells of the central nervous system to regulate appetite and food intak”