Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
By Y. Date, M. Kojima, H. Hosoda, A. Sawaguchi, M. S. Mondal, T. Suganuma, S. Matsukura, K. Kangawa, M. Nakazato. Endocrinology, 2000
1,925 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Physiology
View Paper: https://www.semanticscholar.org/paper/e83709bd959301dffeea0a3612868b5905dd52ab
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In Endocrine and Autonomic Systems
In Physiology
Citations in the corpus
- Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. (2004, background): “Considering that ghrelin is produced predominantly by the oxyntic cells located within the fundus of the stomach (27) and its plasma levels fluctuate with meal cycles (15), it is pertinent to evaluate the actions of peripherally administered ghrelin.”
- Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. (2001, background): “Northern blot analysis shows that ghrelin mRNA is expressed most abundantly in the stomach (3, 13), and circulating ghrelin levels are increased by fasting and reduced by feeding (12).”
- Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. (2004, background): “Introduction Ghrelin is a 28-amino-acid acylated polypeptide secreted predominantly from X/A-like enteroendocrine cells of the stomach (1, 2).”
- Expression of ghrelin receptor mRNA in the rat and the mouse brain (2006, background): “…cells, and is also produced by endocrine cells located in other peripheral tissues, such as the intestines and pancreas (Kojima et al., 1999; Date et al., 2000, 2002; Hosoda et al., 2000; Tschop et al., 2000; Ariyasu et al., 2001; Horvath et al., 2001; Lee et al., 2002; Volante et al.,…”
- Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. (2008, neutral): “(Date et al., 2000; Kojima and Kangawa, 2005).”
- Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. (2002, background): “which are most abundant in the oxyntic mucosa of both species, account for about 20% of the oxyntic gland endocrine cell population (3, 4).”
- Ghrelin causes hyperphagia and obesity in rats. (2001, background): “Ghrelin is synthesized primarily in X/A-like endocrine cells in the oxyntic glands of the stomach and is present in the circulation (7).”
- Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. (2004, background): “and D-(SS) cells (10%), are not ghrelin positive (3, 124).”
- Ghrelin: structure and function. (2005, background): “duodenum, jejunum, ileum, and colon (54, 107, 203).”