Ghrelin causes hyperphagia and obesity in rats.

By A. Wren, C. Small, C. Abbott, W. Dhillo, L. Seal, M. Cohen, R. Batterham, Shahrad Taheri, S. Stanley, M. Ghatei and 1 more. Diabetes, 2001

1,194 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/71c15da01c915833938329a27d1c85fb2dabfe3b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Roger Cone
2. K. Kangawa
3. M. Kojima
4. Matthias Tschöp
5. P. Havel
6. J. Elmquist
7. M. Heiman
8. Clifford B. Saper

In Nutrition and Dietetics

1. Roger Cone
2. K. Kangawa
3. M. Kojima
4. Matthias Tschöp
5. M. Heiman
6. J. Elmquist
7. P. Havel
8. Joseph E LeDoux

In Physiology

1. K. Kangawa
2. M. Kojima
3. Roger Cone
4. P. Havel
5. Matthias Tschöp
6. M. Heiman
7. Shahrad Taheri
8. T. Horvath

Citations in the corpus

• Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. (2005, background): “The administration of exogenous ghrelin increases food intake and, with repeated administration, reduces lipid oxidation and induces weight gain in rodents.(187,188) Hunger and ad libitum food intake are increased during intravenous ghrelin infusion in normal human subjects(189) and in patients with”
• Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index (2004, positive): “Levels of ghrelin, a potent stimulator of appetite [23,24,25], were higher in those with shorter sleep.”
• The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. (2003, background): “…to account for from the pituitary (Arvat et al., 2001). the potent orexigenic effects of ghrelin (Tschop et al., 2000, 2002; Nakazato et al., 2001; Wren et al., 2001a; Model of Ghrelin Action in the Brain The results outlined here provide both anatomical sub-Kamegai et al., 2001; Lu et al.,…”
• Ghrelin: structure and function. (2005, background): “When ghrelin is injected into the cerebral ventricles of rats, their food intake is potently stimulated (122, 173, 211, 246, 266).”
• Deletion of Ghrelin Impairs neither Growth nor Appetite (2003, background): “Ghrelin administration causes an acute increase in appetite and serum ghrelin is upregulated during fasting (33, 40).”
• Inhibition of food intake in obese subjects by peptide YY3-36. (2003, neutral): “Gut hormone PYY(3-36) physiologically inhibits food intake.”
• Expression of ghrelin receptor mRNA in the rat and the mouse brain (2006, methodology): “Our current study confirms the finding by Shuto et al. of GHSR-TH coexpression within the Arc.”