Mammalian ABC transporters in health and disease.

By P. Borst, R. Elferink. Annual Review of Biochemistry, 2002

1,602 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/e79390e2a415bd5c0596ef8f313d36c9482953d3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nutrition and Dietetics

1. C. Wood
2. C. Brauner
3. A. Farrell

In Oncology

1. Colin W. Pouton
2. P. Edwards
3. Michael M. Gottesman
4. D. McClements
5. Jiajia Rao

In Surgery

1. P. Edwards
2. Bart Staels

Citations in the corpus

• Strategies to Address Low Drug Solubility in Discovery and Development (2013, background): “Hanke U, May K, Rozehnal V, Nagel S, Siegmund W, and Weitschies W (2010) Commonly used nonionic surfactants interact differently with the human efflux transporters ABCB1 (p-glycoprotein) and ABCC2 (MRP2).”
• Drug Resistance in Cancer: An Overview (2014, background): “They also play a large role in maintaining the blood-brain barrier [38,39].”
• P-glycoprotein: from genomics to mechanism (2003, background): “Many different mechanisms of MDR have been elucidated, including alterations in cell cycle checkpoints, failure of apoptotic mechanisms, repair of damaged cellular targets, and reduced drug accumulation (reviewed in Borst and Elferink, 2002; Gottesman, 2002).”
• ABC multidrug transporters: structure, function and role in chemoresistance. (2008, neutral): “with a specific disease state [3].”
• Glutathione dysregulation and the etiology and progression of human diseases (2009, background): “A total of nine functional MRP genes have been identified (MRP1/ ABCC1 to MRP9/ABCC9), although the physiological functions of many MRPs remain undefined (Borst and Oude Elferink, 2002; Kruh et al., 2007).”
• Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “The molecular characterization, function, and modes of regulation of the various BA transporters have been reviewed in a recent issue of Physiological Reviews (317) and several other excellent overview articles (27, 305).”
• Homeostasis and toxicology of essential metals (2012, background): “For example, there is evidence that the multidrug resistance protein 2 (MRP2) mediates biliary transport of metals complexed with glutathione (Borst and Elferink, 2002).”
• ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. (2005, background): “ABCG1 and ABCA1 are members of the ATP binding cassette (ABC) superfamily of transmembrane transporters that pump specific substrates across membranes (Borst and Elferink, 2002; Dean et al., 2001).”